Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4666838 | 0.83 | GRIN2B (0.44) | JAK2JAK1GRIN2B | |
| SCHEMBL4663365 | 0.82 | GPR119 (0.52) | GPR119PIK3CD | |
| SCHEMBL4665129 | 0.80 | GPR119 (0.43) | GPR119JAK2JAK1GRIN2BCYP3A4 | |
| SCHEMBL5220949 | 0.75 | PRMT5 (0.47) | GPR119GRIN2BCYP2D6CYP2C9PRMT5 | |
| SCHEMBL4666791 | 0.74 | GPR119 (0.37) | GPR119JAK2JAK1GRIN2BPPARG | |
| SCHEMBL2894884 | 0.74 | TPSAB1 (0.47) | GPR119JAK2JAK1 | |
| SCHEMBL4663070 | 0.74 | GPR119 (0.35) | GPR119JAK2JAK1GRIN2BPPARG | |
| SCHEMBL17148650 | 0.72 | GPR119 (0.47) | GPR119 | |
| SCHEMBL4663071 | 0.70 | JAK2 (0.38) | GPR119JAK2JAK1GRIN2BTLR9 | |
| SCHEMBL10089204 | 0.70 | RAB9A (0.48) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940296-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007114848-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-10-11 | — | — | WO | disclosed |