SCHEMBL466427

SCHEMBL466427

CCOC(=O)C(C)=NN(C)C(=O)Cc1c(CC)cc(C)cc1CC

nearest known ligand 0.38

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.36
ABCB1 P08183 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
GAA P10253 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
LMNA P02545 1/20 0.30
KDM4E B2RXH2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL510087 1.00 MAPT (0.36) MAPTABCB1MEN1KMT2AGAA
SCHEMBL15341148 0.94 MAPT (0.33) MAPTABCB1MEN1KMT2ACYP1A2
SCHEMBL15341149 0.91 MAPT (0.35) MAPTABCB1MEN1KMT2AGAA
SCHEMBL509000 0.91 ABCB1 (0.39) MAPTABCB1MEN1KMT2AGAA
SCHEMBL509001 0.91 ABCB1 (0.39) MAPTABCB1MEN1KMT2AGAA
SCHEMBL15341147 0.88 MAPT (0.36) MAPTABCB1MEN1KMT2AGAA
SCHEMBL12481337 0.85 ABCB1 (0.32) ABCB1MEN1KMT2ACYP1A2CYP2C9
SCHEMBL12481334 0.85 ABCB1 (0.32) ABCB1MEN1KMT2ACYP1A2CYP2C9
SCHEMBL919585 0.85 ABCB1 (0.42) MAPTABCB1KMT2AGAAKDM4E
SCHEMBL12481619 0.84 ABCB1 (0.31) ABCB1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9096533-B2 Pyridazinone compound and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-08-04 US disclosed
US-9096534-B2 Pyridazinone compound and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-08-04 US disclosed
US-9029295-B2 Pyridazinone compound and herbicide and noxious arthropod controlling agent comprising it SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-05-12 US disclosed
US-20150126738-A1 PYRIDAZINONE COMPOUND AND USE THEREOF SUMITOMO CHEMICAL CO (JP) 2015-05-07 US disclosed
US-20150126739-A1 PYRIDAZINONE COMPOUND AND USE THEREOF SUMITOMO CHEMICAL CO (JP) 2015-05-07 US disclosed
US-8962625-B2 Pyridazinone compound and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-02-24 US disclosed
US-20130281299-A1 PYRIDAZINONE COMPOUND AND HERBICIDE AND NOXIOUS ARTHROPOD CONTROLLING AGENT COMPRISING IT SUMITOMO CHEMICAL COMPANY,LIMITED (JP) 2013-10-24 US disclosed
US-8541414-B2 Pyridazinone compound and use thereof as herbicides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-09-24 US disclosed
US-8507410-B2 Pyridazinone compound and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-08-13 US disclosed
US-20120196750-A1 PYRIDAZINONE COMPOUND AND USE THEREOF KIJI TOSHIYUKI (JP) 2012-08-02 US disclosed
US-20110319266-A1 HERBICIDAL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-12-29 US disclosed
US-20100298142-A1 HERBICIDAL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-11-25 US disclosed
US-20100248964-A1 HERBICIDAL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-09-30 US disclosed
WO-2010104217-A1 PYRIDAZINONE COMPOUND AND USE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-09-16 WO disclosed
WO-2010104216-A1 HERBICIDAL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-09-16 WO disclosed
US-20100210462-A1 HERBICIDAL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-08-19 US disclosed
EP-2187744-A2 HERBICIDAL COMPOSITION COMPRISING A PYRIDAZINONE COMPOUND WITH A SPECIFIC HERBICIDE AND A SPECIFIC SAFENER Sumitomo Chemical Company, Limited (JP) 2010-05-26 EP disclosed
US-20090111696-A1 Pyridazinone Compound and Use Thereof as herbicides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-04-30 US disclosed
WO-2009035145-A2 HERBICIDAL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-03-19 WO disclosed
WO-2009035146-A2 HERBICIDAL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-03-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110319266-A1 HERBICIDAL COMPOSITION DDT, EGLN1, ELF3 MAPT 3582/4885ABCB1 2092/4885MEN1 1251/4885
US-20100248964-A1 HERBICIDAL COMPOSITION CHRM2, CHRM1, WEE1 MAPT 4336/4885ABCB1 2961/4885MEN1 4148/4885
US-20150126738-A1 PYRIDAZINONE COMPOUND AND USE THEREOF PDXK, PLPBP, PNPO MAPT 3369/4885ABCB1 1544/4885MEN1 4206/4885
US-20100210462-A1 HERBICIDAL COMPOSITION WEE1, WEE2, H1-3 MAPT 4413/4885ABCB1 2169/4885MEN1 4076/4885
US-20150126739-A1 PYRIDAZINONE COMPOUND AND USE THEREOF PDXK, PLPBP, PNPO MAPT 3369/4885ABCB1 1544/4885MEN1 4206/4885
US-20120196750-A1 PYRIDAZINONE COMPOUND AND USE THEREOF PDXK, PLPBP, PNPO MAPT 3369/4885ABCB1 1544/4885MEN1 4206/4885
US-20130281299-A1 PYRIDAZINONE COMPOUND AND HERBICIDE AND NOXIOUS ARTHROPOD CONTROLLING AGENT COMPRISING IT ACHE, CBR3, DDT MAPT 4682/4885ABCB1 4554/4885MEN1 4347/4885
US-20090111696-A1 Pyridazinone Compound and Use Thereof as herbicides PDXK, DDT, PLPBP MAPT 3414/4885ABCB1 1517/4885MEN1 4455/4885
US-20100298142-A1 HERBICIDAL COMPOSITION CYP2W1, WEE2, CYP2J2 MAPT 4587/4885ABCB1 1820/4885MEN1 3545/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.