Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.72 |
| ▸ | RECQL | P46063 | 1/20 | 0.72 |
| ▸ | PTPRB | P23467 | 3/20 | 0.63 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | ACP1 | P24666 | 1/20 | 0.55 |
| ▸ | AKT1 | P31749 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28914988 | 0.95 | ALDH1A1 (0.65) | ALDH1A1RECQLPTPRBMMP8PTPN2 | |
| SCHEMBL16019074 | 0.93 | ALDH1A1 (0.67) | ALDH1A1RECQLPTPRBMMP8PTPN2 | |
| SCHEMBL28168067 | 0.85 | ALDH1A1 (0.51) | ALDH1A1RECQLPTPRBAKT1CA12 | |
| SCHEMBL1859341 | 0.85 | PTPRB (0.53) | ALDH1A1RECQLPTPRBMMP8PTPN2 | |
| SCHEMBL8392933 | 0.84 | ALDH1A1 (0.51) | ALDH1A1RECQLPTPRBMMP8PTPN2 | |
| SCHEMBL27395266 | 0.84 | ALDH1A1 (1.00) | ALDH1A1RECQLPTPRBMMP8PTPN2 | |
| SCHEMBL560838 | 0.83 | ALDH1A1 (0.51) | ALDH1A1RECQLPTPRBMMP8PTPN2 | |
| SCHEMBL2347910 | 0.82 | PTPRB (0.55) | ALDH1A1RECQLPTPRBMMP8PTPN2 | |
| SCHEMBL560683 | 0.81 | ALDH1A1 (0.49) | ALDH1A1RECQLPTPRBMMP8PTPN2 | |
| SCHEMBL560684 | 0.81 | ALDH1A1 (0.49) | ALDH1A1RECQLPTPRBMMP8PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106946724-B | The synthetic method of monoamine base inhibitor class intermediate 2- acetylaminohydroxyphenylarsonic acid 2- benzyl malonic acid mono ethyl ester | 苏州汉德创宏生化科技有限公司 | 2019-03-22 | — | — | CN | claimed |
| EP-2765859-B1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2017-01-18 | — | — | EP | disclosed |
| US-9505730-B2 | Mineralocorticoid receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-11-29 | — | — | US | disclosed |
| EP-2765860-B1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2016-08-17 | — | — | EP | disclosed |
| US-9193717-B2 | Mineralocorticoid receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2015-11-24 | — | — | US | disclosed |
| US-9085568-B2 | Mineralocorticoid receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2015-07-21 | — | — | US | disclosed |
| US-20150166490-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2015-06-18 | — | — | US | disclosed |
| US-20140275133-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2014-09-18 | — | — | US | disclosed |
| US-20140256723-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2014-09-11 | — | — | US | disclosed |
| WO-2013055607-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2013-04-18 | — | — | WO | disclosed |
| WO-2013055608-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2013-04-18 | — | — | WO | disclosed |
| WO-2013055606-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2013-04-18 | — | — | WO | disclosed |
| US-20080064736-A1 | Substituted 2-Pyrrolidone Derivatives as Fungicides and Insecticides | BAYER CROPSCIENCE AG (DE) | 2008-03-13 | — | — | US | disclosed |
| US-20080064736-A1 | Substituted 2-Pyrrolidone Derivatives as Fungicides and Insecticides | BAYER CROPSCIENCE AG (DE) | 2008-03-13 | — | — | US | disclosed |
| US-20080064736-A1 | Substituted 2-Pyrrolidone Derivatives as Fungicides and Insecticides | BAYER CROPSCIENCE AG (DE) | 2008-03-13 | — | — | US | disclosed |
| CN-101133022-A | Substituted 2-pyrrolidone derivatives as fungicides and insecticides | BAYER CROPSCIENCE AG (DE) | 2008-02-27 | — | — | CN | disclosed |
| EP-1771411-A1 | SUBSTITUTED 2-PYRROLIDONE DERIVATIVES AS FUNGICIDES AND INSECTICIDES | Bayer CropScience Aktiengesellschaft (DE) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006005551-A1 | SUBSTITUTED 2-PYRROLIDONE DERIVATIVES AS FUNGICIDES AND INSECTICIDES | BAYER CROPSCIENCE AG (DE) | 2006-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256723-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | NR3C2, MC2R, REN | ALDH1A1 769/4885RECQL 3695/4885PTPRB 1452/4885 |
| US-20150166490-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | NR3C2, MC2R, REN | ALDH1A1 784/4885RECQL 3597/4885PTPRB 1491/4885 |
| US-20080064736-A1 | Substituted 2-Pyrrolidone Derivatives as Fungicides and Insecticides | DDT, PPM1F, PPM1D | ALDH1A1 1151/4885RECQL 4355/4885PTPRB 177/4885 |
| US-20140275133-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | NR3C2, MC2R, CYP11B2 | ALDH1A1 736/4885RECQL 3589/4885PTPRB 1793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.