Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.52 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.49 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5110651 | 1.00 | TSHR (0.60) | TSHRACHEALDH1A1S1PR5HDAC1 | |
| SCHEMBL8207838 | 0.92 | ACHE (0.65) | TSHRACHEALDH1A1S1PR5HDAC1 | |
| SCHEMBL8228028 | 0.88 | TSHR (0.59) | TSHRACHEHDAC1HDAC8HDAC6 | |
| SCHEMBL4662897 | 0.82 | KDM4E (0.54) | TSHRALDH1A1SIGMAR1PDCD1LG2CD274 | |
| SCHEMBL5107192 | 0.82 | KDM4E (0.54) | TSHRALDH1A1SIGMAR1PDCD1LG2CD274 | |
| SCHEMBL2160181 | 0.82 | ALDH1A1 (0.61) | ALDH1A1S1PR5PDCD1LG2CD274SMN1; SMN2 | |
| SCHEMBL4662970 | 0.82 | S1PR5 (0.53) | ALDH1A1S1PR5PDCD1LG2CD274 | |
| SCHEMBL4769598 | 0.82 | S1PR5 (0.53) | ALDH1A1S1PR5PDCD1LG2CD274 | |
| SCHEMBL1893898 | 0.81 | ALDH1A1 (0.60) | ALDH1A1S1PR5SIGMAR1MEN1KMT2A | |
| SCHEMBL4724721 | 0.81 | ALDH1A1 (0.85) | ALDH1A1S1PR5PDCD1LG2CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007787-A2 | HCV INHIBITORS COMPRISING BETA AMINO ACIDS AND THEIR USES | Novartis AG (CH) | 2008-12-31 | — | — | EP | disclosed |
| US-20080045530-A1 | Organic Compounds and Their Uses | BRANDL TRIXI | 2008-02-21 | — | — | US | disclosed |
| WO-2007121124-A2 | HCV INHIBITORS COMPRISING BETA AMINO ACIDS AND THEIR USES | NOVARTIS AG (CH) | 2007-10-25 | — | — | WO | disclosed |
| WO-2007120595-A2 | AMINES FOR THE TREATMENT OF HCV | NOVARTIS AG (CH) | 2007-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045530-A1 | Organic Compounds and Their Uses | OAT, OTC, AOX1 | TSHR 3678/4885ACHE 254/4885ALDH1A1 135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.