SCHEMBL4666033

SCHEMBL4666033

Nc1cccc[n+]1C=Cc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.43
CYP19A1 P11511 2/20 0.43
MAOA P21397 2/20 0.43
CHAT P28329 2/20 0.41
HTT P42858 1/20 0.40
NFE2L2 Q16236 2/20 0.35
GRM4 Q14833 1/20 0.35
ALDH1A1 P00352 3/20 0.34
TRPA1 O75762 1/20 0.34
LMNA P02545 1/20 0.34
ALOX5 P09917 1/20 0.34
MAPK1 P28482 1/20 0.34
KDM4E B2RXH2 2/20 0.34
MEN1 O00255 1/20 0.34
HPGD P15428 1/20 0.34
KMT2A Q03164 1/20 0.34
HDAC3 O15379 1/20 0.34
HDAC4 P56524 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC2 Q92769 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8625483 0.76 CHAT (0.41) MAOBMAOACHATHTTNFE2L2
SCHEMBL3319557 0.76 CHAT (0.45) MAOBCHATNFE2L2GRM4ALDH1A1
SCHEMBL3317628 0.76 CHAT (0.41) MAOBCHATHTTALDH1A1KDM4E
SCHEMBL15517343 0.75 CYP19A1 (0.48) MAOBCYP19A1MAOACHATHTT
SCHEMBL16538878 0.74 CHAT (0.48) MAOBCYP19A1MAOACHATHTT
SCHEMBL999266 0.73 ALDH1A1 (0.41) MAOBMAOACHATHTTNFE2L2
SCHEMBL4144762 0.73 HDAC8 (0.46) MAOBCYP19A1MAOACHATNFE2L2
SCHEMBL422596 0.72 CHAT (0.50) CHATHDAC8HDAC6
Hydrochloric Acid SCHEMBL13277619 0.72 HDAC8 (0.44) MAOBCYP19A1MAOACHATNFE2L2
SCHEMBL8607279 0.72 RELA (0.44) MAOBCHATHTTNFE2L2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1019722-B1 POLYMERIC FLUOROPHORES ENHANCED BY MOIETIES PROVIDING A HYDROPHOBIC AND CONFORMATIONALLY RESTRICTIVE MICROENVIRONMENT ABBOTT LAB (US) 2003-04-09 EP claimed
EP-1019722-A1 POLYMERIC FLUOROPHORES ENHANCED BY MOIETIES PROVIDING A HYDROPHOBIC AND CONFORMATIONALLY RESTRICTIVE MICROENVIRONMENT Abbott Laboratories (US) 2000-07-19 EP claimed
US-5834230-A Viscosity Probe MCGILL UNIVERSITY (CA) 1998-11-10 US claimed
WO-1997028447-A1 POLYMERIC FLUOROPHORES ENHANCED BY MOIETIES PROVIDING A HYDROPHOBIC AND CONFORMATIONALLY RESTRICTIVE MICROENVIRONMENT ABBOTT LABORATORIES (US) 1997-08-07 WO claimed
EP-4419206-B1 COMPOUNDS FOR THE TREATMENT OF MALARIA FUNDACIO INST DE BIOENGINYERIA DE CATALUNYA (ES) 2025-09-17 EP disclosed
US-20240415825-A1 COMPOUNDS FOR THE TREATMENT OF MALARIA Fundación Privada Instituto De Salud Global Barcelona (ES) 2024-12-19 US disclosed
EP-4419206-A1 COMPOUNDS FOR THE TREATMENT OF MALARIA Fundacio Institut de Bioenginyeria de Catalunya (ES) 2024-08-28 EP disclosed
CN-118475559-A Compounds for malaria treatment 加泰罗尼亚生物工程基金会研究所 2024-08-09 CN disclosed
WO-2023067170-A1 COMPOUNDS FOR THE TREATMENT OF MALARIA FUNDACIÓ INSTITUT DE BIOENGINYERIA DE CATALUNYA (ES) 2023-04-27 WO disclosed
US-20080122428-A1 Optimized Determination of Voltage Changes Using a Voltage-Sensitive Dye MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNGDER WISSENSCHAFTEN E. V. (DE) 2008-05-29 US disclosed
US-20070276208-A1 Process for identifying and treating specified cell types BIOMED SOLUTIONS, LLC (US) 2007-11-29 US disclosed
US-7244232-B2 Process for identifying cancerous and/or metastatic cells of a living organism BIOMED SOLUTIONS, LLC (US) 2007-07-17 US disclosed
EP-1019722-A1 POLYMERIC FLUOROPHORES ENHANCED BY MOIETIES PROVIDING A HYDROPHOBIC AND CONFORMATIONALLY RESTRICTIVE MICROENVIRONMENT Abbott Laboratories (US) 2000-07-19 EP disclosed
EP-1019722-A1 POLYMERIC FLUOROPHORES ENHANCED BY MOIETIES PROVIDING A HYDROPHOBIC AND CONFORMATIONALLY RESTRICTIVE MICROENVIRONMENT Abbott Laboratories (US) 2000-07-19 EP disclosed
US-5994143-A FLUORESCENT CONJUGATES SUITABLE FOR USE IN FLOW CYTOMETRY AND OTHER BIOLOGICAL APPLICATIONS; THE FLUORESCENT CONJUGATES COMPRISE AN ANTIBODY HAVING A POLYMERIC DYE BOUND THERETO ABBOTT LABORATORIES (US) 1999-11-30 US disclosed
US-5994143-A FLUORESCENT CONJUGATES SUITABLE FOR USE IN FLOW CYTOMETRY AND OTHER BIOLOGICAL APPLICATIONS; THE FLUORESCENT CONJUGATES COMPRISE AN ANTIBODY HAVING A POLYMERIC DYE BOUND THERETO ABBOTT LABORATORIES (US) 1999-11-30 US disclosed
US-5834230-A Viscosity Probe MCGILL UNIVERSITY (CA) 1998-11-10 US disclosed
US-5834230-A Viscosity Probe MCGILL UNIVERSITY (CA) 1998-11-10 US disclosed
WO-1997028447-A1 POLYMERIC FLUOROPHORES ENHANCED BY MOIETIES PROVIDING A HYDROPHOBIC AND CONFORMATIONALLY RESTRICTIVE MICROENVIRONMENT ABBOTT LABORATORIES (US) 1997-08-07 WO disclosed
WO-1997028447-A1 POLYMERIC FLUOROPHORES ENHANCED BY MOIETIES PROVIDING A HYDROPHOBIC AND CONFORMATIONALLY RESTRICTIVE MICROENVIRONMENT ABBOTT LABORATORIES (US) 1997-08-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240415825-A1 COMPOUNDS FOR THE TREATMENT OF MALARIA ABAT, GLS2, CPS1 MAOB 1035/4885CYP19A1 4217/4885MAOA 1946/4885
US-20080122428-A1 Optimized Determination of Voltage Changes Using a Voltage-Sensitive Dye HVCN1, CACNG5, CACNB4 MAOB 2779/4885CYP19A1 4827/4885MAOA 3172/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.