Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7567519 | 0.83 | KDM4E (0.36) | CA1CA12CA2CA14KMT2A | |
| SCHEMBL17545124 | 0.82 | TDP1 (0.47) | CA1CA12CA2CA14SERPINE1 | |
| SCHEMBL7553791 | 0.78 | DNM1 (0.46) | CA1CA12CA2CA14SERPINE1 | |
| SCHEMBL5454493 | 0.78 | DNM1 (0.46) | CA1CA12CA2CA14SERPINE1 | |
| SCHEMBL7160479 | 0.78 | DNM1 (0.46) | CA1CA12CA2CA14SERPINE1 | |
| SCHEMBL2058088 | 0.75 | CA1 (0.63) | CA1CA12CA2CA14KMT2A | |
| SCHEMBL11871908 | 0.75 | CA1 (0.33) | CA1CA12CA2CA14 | |
| SCHEMBL145294 | 0.75 | CHRM2 (0.30) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL2359551 | 0.73 | KDM4E (0.33) | CA1KMT2ACHRM2CHRM4CHRM5 | |
| SCHEMBL2731669 | 0.73 | TRPA1 (0.36) | CA1CA12CA2CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1653962-A4 | PYRAZINE MODULATORS OF CANNABINOID RECEPTORS | BRISTOL MYERS SQUIBB CO (US) | 2008-06-11 | — | — | EP | disclosed |
| EP-1653962-A2 | PYRAZINE MODULATORS OF CANNABINOID RECEPTORS | Bristol-Myers Squibb Company (US) | 2006-05-10 | — | — | EP | disclosed |
| EP-1651722-A1 | WATER-BASED POLYMER COMPOSITION AND ARTICLES MADE THEREFROM | Solvay SA (BE) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005016286-A2 | PYRAZINE MODULATORS OF CANNABINOID RECEPTORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-24 | — | — | WO | disclosed |
| WO-2005012423-A1 | WATER-BASED POLYMER COMPOSITION AND ARTICLES MADE THEREFROM | SOLVAY SA (BE) | 2005-02-10 | — | — | WO | disclosed |