Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 9/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.62 |
| ▸ | HTR1A | P08908 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | THPO | P40225 | 2/20 | 0.53 |
| ▸ | MTOR | P42345 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4667575 | 0.80 | CYP2D6 (0.58) | SLC6A4SLC6A3SLC6A2HTR1ACYP2C9 | |
| SCHEMBL4667595 | 0.75 | FFAR1 (0.52) | SLC6A4SLC6A3SLC6A2SMN1; SMN2CYP2C9 | |
| SCHEMBL10357800 | 0.74 | SIGMAR1 (0.81) | SLC6A4SLC6A3SLC6A2HTR1ASMN1; SMN2 | |
| SCHEMBL10554467 | 0.72 | SLC6A4 (0.62) | SLC6A4SLC6A3SLC6A2SMN1; SMN2CYP2C9 | |
| SCHEMBL30671730 | 0.72 | SIGMAR1 (0.73) | SLC6A4SLC6A2HTR1ASIGMAR1KCNH2 | |
| SCHEMBL15442411 | 0.72 | HRH3 (0.62) | SLC6A4SLC6A2HTR1ASIGMAR1MAPT | |
| Hydrochloric Acid SCHEMBL10573209 | 0.71 | SIGMAR1 (0.59) | SLC6A4SLC6A3SLC6A2SMN1; SMN2MAPK1 | |
| SCHEMBL350747 | 0.70 | HTR1A (0.88) | SLC6A4SLC6A3SLC6A2HTR1AKCNH2 | |
| SCHEMBL1506074 | 0.70 | SLC6A3 (0.79) | SLC6A3 | |
| SCHEMBL2115675 | 0.70 | ADRB1 (0.72) | HTR1ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0983222-A1 | PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CEREBRAL AMYLOIDOSIS | NYMOX CORPORATION (CA) | 2000-03-08 | — | — | EP | disclosed |
| WO-1998052898-A1 | PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CEREBRAL AMYLOIDOSIS | NYMOX CORPORATION (CA) | 1998-11-26 | — | — | WO | disclosed |