Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.43 |
| ▸ | F10 | P00742 | 3/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4669143 | 1.00 | L3MBTL1 (0.48) | L3MBTL1KMT2AGRM2F10ITGB3 | |
| SCHEMBL4670887 | 0.85 | LMNA (0.46) | KMT2AGRM2MAOACYP3A4 | |
| SCHEMBL4670885 | 0.85 | LMNA (0.46) | KMT2AGRM2MAOACYP3A4 | |
| SCHEMBL7466423 | 0.84 | ITGB3 (0.51) | F10ITGB3PRSS1PRSS2ITGA2B | |
| SCHEMBL4670666 | 0.84 | GRM2 (0.54) | GRM2F10 | |
| SCHEMBL2322579 | 0.84 | GRM2 (0.54) | GRM2F10 | |
| SCHEMBL4669702 | 0.84 | GRM2 (0.54) | GRM2F10 | |
| SCHEMBL7467481 | 0.82 | MAOA (0.41) | GRM2F10ITGB3PRSS1PRSS2 | |
| SCHEMBL6613011 | 0.79 | MAOA (0.58) | L3MBTL1GRM2MAOA | |
| SCHEMBL6613015 | 0.79 | MAOA (0.58) | L3MBTL1GRM2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101309911-A | HIV-1 protease inhibitors, methods of making and methods of using the same | UNIV MASSACHUSETTS (US) | 2008-11-19 | — | — | CN | disclosed |
| EP-1937655-A1 | HIV-1 PROTEASE INHIBITORS, AND METHODS OF MAKING AND USING THEM | University of Massachusetts (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007002173-A1 | HIV-1 PROTEASE INHIBITORS, AND METHODS OF MAKING AND USING THEM | UNIVERSITY OF MASSACHUSETTS (US) | 2007-01-04 | — | — | WO | disclosed |