Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.71 |
| ▸ | DRD3 | P35462 | 7/20 | 0.71 |
| ▸ | DRD4 | P21917 | 4/20 | 0.71 |
| ▸ | FAAH | O00519 | 1/20 | 0.69 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.69 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.63 |
| ▸ | HTR2A | P28223 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL253846 | 0.84 | DRD2 (0.90) | DRD2DRD3DRD4SLC6A2SLC6A4 | |
| SCHEMBL3654118 | 0.84 | DRD2 (0.74) | DRD2DRD3DRD4SLC6A2SLC6A4 | |
| SCHEMBL10664987 | 0.83 | DRD2 (1.00) | DRD2DRD3DRD4SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL3661243 | 0.83 | DRD2 (0.73) | DRD2DRD3DRD4SLC6A2SLC6A4 | |
| SCHEMBL16403787 | 0.82 | DRD3 (1.00) | DRD2DRD3DRD4FAAHHTR2A | |
| SCHEMBL252086 | 0.82 | DRD2 (0.88) | DRD2DRD3DRD4SLC6A2SLC6A4 | |
| SCHEMBL252898 | 0.81 | SLC6A2 (0.74) | DRD2DRD3DRD4SLC6A2SLC6A4 | |
| SCHEMBL13532791 | 0.80 | DRD2 (0.94) | DRD2DRD3DRD4SLC6A2SLC6A4 | |
| SCHEMBL246381 | 0.80 | LMNA (0.76) | DRD2DRD3SLC6A2SLC6A4ADRA1A | |
| SCHEMBL3411899 | 0.80 | SLC6A2 (0.76) | DRD2DRD3DRD4SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2600863-B1 | USE OF SIGMA LIGANDS IN OPIOID-INDUCED HYPERALGESIA | ESTEVE LABOR DR (ES) | 2018-03-28 | — | — | EP | disclosed |
| EP-2646025-B1 | USE OF SIGMA LIGANDS IN BONE CANCER PAIN | ESTEVE LABOR DR (ES) | 2017-03-15 | — | — | EP | disclosed |
| EP-2531191-B1 | Sigma ligands for use in the prevention and/or treatment of postoperative pain | ESTEVE LABOR DR (ES) | 2016-03-30 | — | — | EP | disclosed |
| EP-2571501-B1 | SIGMA LIGANDS FOR THE PREVENTION AND/OR TREATMENT OF EMESIS INDUCED BY CHEMOTHERAPY OR RADIOTHERAPY | ESTEVE LABOR DR (ES) | 2016-03-02 | — | — | EP | disclosed |
| EP-2460519-A1 | Use of sigma ligands in bone cancer pain | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2012-06-06 | — | — | EP | disclosed |
| EP-2415471-A1 | Use of sigma ligands in opioid-induced hyperalgesia | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2012-02-08 | — | — | EP | disclosed |
| EP-2388005-A1 | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2011-11-23 | — | — | EP | disclosed |
| EP-2353598-A1 | Sigma ligands for use in the prevention and/or treatment of postoperative pain | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2011-08-10 | — | — | EP | disclosed |