Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 12/20 | 0.79 |
| ▸ | BCHE | P06276 | 3/20 | 0.79 |
| ▸ | ACHE | P22303 | 3/20 | 0.79 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | GAA | P10253 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | SNCA | P37840 | 2/20 | 0.56 |
| ▸ | CYBB | P04839 | 2/20 | 0.56 |
| ▸ | NOX3 | Q9HBY0 | 2/20 | 0.56 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.56 |
| ▸ | APP | P05067 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Urea SCHEMBL27590816 | 0.94 | NOX1 (0.79) | NOX1BCHEACHEMAPTGAA | |
| SCHEMBL1509893 | 0.94 | NOX1 (0.84) | NOX1BCHEACHEMAPTGAA | |
| SCHEMBL236458 | 0.89 | NOX1 (1.00) | NOX1BCHEACHEMAPTGAA | |
| SCHEMBL29384266 | 0.89 | NOX1 (1.00) | NOX1BCHEACHEMAPTGAA | |
| SCHEMBL28679021 | 0.87 | NOX1 (0.96) | NOX1BCHEACHEMAPTGAA | |
| SCHEMBL28232162 | 0.87 | NOX1 (0.96) | NOX1BCHEACHEMAPTGAA | |
| SCHEMBL1509784 | 0.84 | NOX1 (0.68) | NOX1BCHEACHEMAPTGAA | |
| SCHEMBL1855994 | 0.83 | NOX1 (0.65) | NOX1BCHEACHEMAPTGAA | |
| Phenothiazine SCHEMBL1509832 | 0.80 | NOX1 (0.74) | NOX1BCHEACHEMAPTGAA | |
| Phenothiazine SCHEMBL7978596 | 0.80 | NOX1 (0.74) | NOX1BCHEACHEMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1923386-A2 | Carbamate caspase inhibitors and uses thereof | Vertex Pharmceuticals Incorporated (US) | 2008-05-21 | — | — | EP | disclosed |
| EP-1268425-B1 | CARBAMATE CASPASE INHIBITORS AND USES THEREOF | VERTEX PHARMA (US) | 2008-01-23 | — | — | EP | disclosed |
| CN-1994298-A | Carbamate aspartic acid specific cysteine proteinase inhibitors and uses thereof | VERTEX PHARMA (US) | 2007-07-11 | — | — | CN | disclosed |
| US-7074782-B2 | Carbamate caspase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-07-11 | — | — | US | disclosed |
| US-20040053920-A1 | Carbamate caspase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2004-03-18 | — | — | US | disclosed |
| US-6689784-B2 | CONTROLLING CELL APOPTOSIS | VERTEX PHARMACEUTICALS INCORPORATED | 2004-02-10 | — | — | US | disclosed |
| EP-1268425-A2 | CARBAMATE CASPASE INHIBITORS AND USES THEREOF | Vertex Pharmaceuticals Incorporated (US) | 2003-01-02 | — | — | EP | disclosed |
| US-20020028803-A1 | Carbamate caspase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2002-03-07 | — | — | US | disclosed |
| WO-2001072707-A2 | CARBAMATE CASPASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2001-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020028803-A1 | Carbamate caspase inhibitors and uses thereof | CASP1, CASP2, CASP3 | NOX1 325/4885BCHE 89/4885ACHE 866/4885 |
| US-20040053920-A1 | Carbamate caspase inhibitors and uses thereof | CASP1, CASP2, CASP3 | NOX1 325/4885BCHE 89/4885ACHE 866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.