Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EYA3 | Q99504 | 4/20 | 0.64 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | TTR | P02766 | 2/20 | 0.59 |
| ▸ | PGR | P06401 | 2/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.59 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.59 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | DRD1 | P21728 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | PDE4A | P27815 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9347209 | 0.87 | CYP2C9 (0.61) | EYA3SLC22A12CYP2C19CYP2C9KMT2A | |
| SCHEMBL27935343 | 0.86 | EYA3 (0.77) | EYA3SLC22A12CYP2C19CYP2C9KMT2A | |
| SCHEMBL4670184 | 0.85 | EYA3 (0.66) | EYA3SLC22A12CYP2C19CYP2C9KMT2A | |
| SCHEMBL2943743 | 0.84 | PTPN1 (0.67) | EYA3CYP2C9TTRNR1H4PTPN1 | |
| Hydrochloric Acid SCHEMBL9350957 | 0.83 | EYA3 (0.64) | EYA3SLC22A12CYP2C19CYP2C9KMT2A | |
| SCHEMBL28131231 | 0.83 | EYA3 (0.64) | EYA3SLC22A12CYP2C19CYP2C9KMT2A | |
| SCHEMBL1287913 | 0.82 | EYA3 (0.81) | EYA3SLC22A12CYP2C19CYP2C9KMT2A | |
| SCHEMBL9605230 | 0.80 | EYA3 (0.43) | EYA3SLC22A12CYP2C19CYP2C9KMT2A | |
| SCHEMBL12286119 | 0.78 | EYA3 (0.79) | EYA3SLC22A12CYP2C19CYP2C9KMT2A | |
| Benzarone SCHEMBL29576057 | 0.78 | EYA3 (1.00) | EYA3SLC22A12CYP2C19CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397341-B1 | 6-(ARYL-AMIDO OR ARYL-AMIDOMETHYL)-NAPHTHALEN-2-YLOXY-ACIDIC DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | WYETH CORP (US) | 2008-08-06 | — | — | EP | disclosed |
| EP-1397341-A1 | 6-(ARYL-AMIDO OR ARYL-AMIDOMETHYL)-NAPHTHALEN-2-YLOXY-ACIDIC DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | Wyeth (US) | 2004-03-17 | — | — | EP | disclosed |
| US-6589970-B2 | This invention provides novel compounds, pharmaceutical compositions and methods of treating thrombotic disorders in mammals, the compounds having the formula: | WYETH | 2003-07-08 | — | — | US | disclosed |
| US-20030045560-A1 | 6-(Aryl-amido or aryl-amidomethyl)-naphthalen-2-yloxy-acidic derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) | WYETH | 2003-03-06 | — | — | US | disclosed |
| WO-2003000649-A1 | 6-(ARYL-AMIDO OR ARYL-AMIDOMETHYL)-NAPHTHALEN-2-YLOXY-ACIDIC DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | WYETH (US) | 2003-01-03 | — | — | WO | disclosed |
| EP-0338746-B1 | 2-Alkyl-3-benzoylbenzofurans and pharmaceutical compositions containing them | TARO PHARMA IND (IL) | 1994-08-31 | — | — | EP | disclosed |
| EP-0338746-A1 | 2-Alkyl-3-benzoylbenzofurans and pharmaceutical compositions containing them | Taro Pharmaceutical Industries Ltd. (IL) | 1989-10-25 | — | — | EP | disclosed |
| US-4831054-A | 2-Alkyl-3-benzoylbenzofurans useful for treating cardiac arrhythmia | TARO PHARMACEUTICALS, LTD. (IL) | 1989-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045560-A1 | 6-(Aryl-amido or aryl-amidomethyl)-naphthalen-2-yloxy-acidic derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) | SERPINC1, F11, SERPINE1 | EYA3 3991/4885SLC22A12 3642/4885CYP2C19 1188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.