Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | EIF4E | P06730 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3566374 | 0.84 | NR4A2 (0.49) | TDP1ALDH1A1HRH2HRH1MAOB | |
| SCHEMBL4674819 | 0.82 | PTGER4 (0.47) | FFAR1NPC1RAB9AMAPT | |
| SCHEMBL4671589 | 0.76 | EIF4E (0.42) | TDP1ALDH1A1HRH2HRH1MAOB | |
| SCHEMBL4675231 | 0.75 | LMNA (0.48) | TDP1ALDH1A1HRH2HRH1MAOB | |
| SCHEMBL3562225 | 0.74 | MAOB (0.54) | TDP1ALDH1A1HRH2HRH1MAOB | |
| SCHEMBL3569402 | 0.73 | POLB (0.67) | TDP1ALDH1A1PTGESMEN1KMT2A | |
| SCHEMBL3557707 | 0.71 | MRGPRX4 (0.57) | RAB9A | |
| SCHEMBL3555525 | 0.71 | MMP13 (0.46) | TDP1ALDH1A1HRH2HRH1NPC1 | |
| SCHEMBL3562475 | 0.70 | MRGPRX4 (0.58) | TDP1ALDH1A1HRH2HRH1MAOB | |
| SCHEMBL3335019 | 0.68 | ALDH1A1 (0.69) | TDP1ALDH1A1HRH2HRH1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663936-B1 | BIARYLOXYMETHYLARENE-CARBOXYLIC ACIDS | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | claimed |