Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1152098 | 0.81 | DRD4 (0.48) | ALDH1A1TDP1KDM4EMAPTHTT | |
| Hydrochloric Acid SCHEMBL9112489 | 0.79 | MAPT (0.48) | ALDH1A1TDP1KDM4EMAPTHTT | |
| SCHEMBL7782495 | 0.74 | CHRNB2 (0.51) | CYP2D6CYP19A1TDP1LMNAKMT2A | |
| SCHEMBL27687099 | 0.73 | EPHX1 (0.70) | CYP1A2LMNAHTTNAMPTHPGD | |
| SCHEMBL7103959 | 0.73 | DRD4 (0.64) | MAPK1LMNACHRNB2CHRNA4 | |
| SCHEMBL22100463 | 0.73 | LMNA (0.54) | CYP1A2CYP19A1ALDH1A1TP53TDP1 | |
| SCHEMBL21058280 | 0.73 | SMN1; SMN2 (0.50) | MAPK1LTA4HALDH1A1TP53TDP1 | |
| SCHEMBL30150593 | 0.73 | RAB9A (0.62) | MAPK1ALDH1A1POLBMAPTMEN1 | |
| SCHEMBL1323646 | 0.73 | RAB9A (0.62) | MAPK1ALDH1A1POLBMAPTMEN1 | |
| SCHEMBL1042402 | 0.72 | CYP1A2 (0.88) | MAPK1LTA4HCYP1A2CYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951689-A1 | P2X7 RECEPTOR ANTAGONISTS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056046-A1 | P2X7 RECEPTOR ANTAGONISTS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2007-05-18 | — | — | WO | disclosed |