SCHEMBL467398

SCHEMBL467398

CCCCC(CCO)c1cccc2ccccc12

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
KCNH2 Q12809 2/20 0.40
SLC6A4 P31645 1/20 0.40
KMT2A Q03164 2/20 0.39
CYSLTR2 Q9NS75 1/20 0.39
CYSLTR1 Q9Y271 1/20 0.39
GAA P10253 1/20 0.39
KDM4E B2RXH2 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
TSHR P16473 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11280291 0.92 ALDH1A1 (0.47) ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4
SCHEMBL7385975 0.90 ALDH1A1 (0.43) ALDH1A1CYP1A2CYP2C9CYP2C19KCNH2
SCHEMBL7381122 0.89 ALDH1A1 (0.42) ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4
SCHEMBL10580910 0.89 ALDH1A1 (0.44) ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4
SCHEMBL2127289 0.89 ALDH1A1 (0.44) ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4
SCHEMBL10579548 0.87 KDM4E (0.45) ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4
SCHEMBL30954270 0.87 KDM4E (0.45) ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4
SCHEMBL2126529 0.85 ALDH1A1 (0.44) ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4
SCHEMBL7383920 0.85 CYP2C9 (0.44) ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4
SCHEMBL10580574 0.85 KDM4E (0.46) ALDH1A1CYP1A2CYP2C9CYP2C19SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 115 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150150819-A1 COMPOSITIONS CONTAINING OPIOID ANTAGONISTS MERCK SHARP & DOHME CORP. 2015-06-04 US disclosed
US-20150126554-A1 METHODS OF PREVENTING AND TREATING GASTROINTESTINAL DYSFUNCTION ADOLOR CORPORATION 2015-05-07 US disclosed
US-8946262-B2 Methods of preventing and treating gastrointestinal dysfunction ADOLOR CORPORATION (US) 2015-02-03 US disclosed
US-8895560-B2 Opioid antagonists ADOLOR CORPORATION (US) 2014-11-25 US disclosed
US-20140303211-A1 COMPOSITIONS CONTAINING OPIOID ANTAGONISTS MERCK SHARP & DOHME CORP. 2014-10-09 US disclosed
US-20140186951-A1 NOVEL OPIOID ANTAGONISTS ADOLOR CORPORATION (US) 2014-07-03 US disclosed
US-20140057947-A1 COMPOSITIONS CONTAINING OPIOID ANTAGONISTS ADOLOR CORPORATION (US) 2014-02-27 US disclosed
US-8598207-B2 Compositions containing opioid antagonists ADOLOR CORPORATION (US) 2013-12-03 US disclosed
US-20130317035-A1 NOVEL OPIOID ANTAGONISTS ADOLOR CORPORATION (US) 2013-11-28 US disclosed
US-8580788-B2 Opioid antagonists ADOLOR CORPORATION (US) 2013-11-12 US disclosed
US-20050054630-A1 Fused bicyclic carboxamide derivatives and methods of their use CUBIST PHARMACEUTICALS, INC. 2005-03-10 US disclosed
US-6852713-B2 Lactam derivatives and methods of their use ADOLOR CORPORATION (US) 2005-02-08 US disclosed
WO-2005004796-A2 SULFONYLAMINO PHENYLACETAMIDE DERIVATIVES AND METHODS OF THEIR USE ADOLOR CORPORATION (US) 2005-01-20 WO disclosed
WO-2004112704-A2 SUBSTITUTED PIPERIDINE COMPOUNDS AND METHODS OF THEIR USE ADOLOR CORPORATION (US) 2004-12-29 WO disclosed
US-20040254218-A1 Substituted piperidine compounds and methods of their use CUBIST PHARMACEUTICALS, INC. 2004-12-16 US disclosed
US-20040254156-A1 Sulfonylamino phenylacetamide derivatives and methods of their use CALIXA THERAPEUTICS, INC. 2004-12-16 US disclosed
WO-2004093796-A2 LACTAM DERIVATIVES AND METHODS OF THEIR USE ADOLOR CORPORATION (US) 2004-11-04 WO disclosed
US-20040209857-A1 Lactam derivatives and methods of their use ADOLOR CORPORATION 2004-10-21 US disclosed
WO-2004082623-A2 SUBSTITUTED PIPERIDINE COMPOUNDS ADOLOR CORPORATION (US) 2004-09-30 WO disclosed
US-20040186135-A1 Substituted piperidine compounds CUBIST PHARMACEUTICALS, INC. 2004-09-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140057947-A1 COMPOSITIONS CONTAINING OPIOID ANTAGONISTS OPRK1, OPRL1, OPRM1 ALDH1A1 1750/4885CYP1A2 157/4885CYP2C9 173/4885
US-20130317035-A1 NOVEL OPIOID ANTAGONISTS OPRK1, OPRM1, OPRL1 ALDH1A1 761/4885CYP1A2 474/4885CYP2C9 720/4885
US-20040254218-A1 Substituted piperidine compounds and methods of their use OPRM1, OPRK1, OPRD1 ALDH1A1 438/4885CYP1A2 332/4885CYP2C9 321/4885
US-20040186135-A1 Substituted piperidine compounds OPRK1, OPRD1, OPRM1 ALDH1A1 431/4885CYP1A2 558/4885CYP2C9 796/4885
US-20040254156-A1 Sulfonylamino phenylacetamide derivatives and methods of their use CYP2E1, CYP2D6, CYP3A43 ALDH1A1 94/4885CYP1A2 11/4885CYP2C9 10/4885
US-20150126554-A1 METHODS OF PREVENTING AND TREATING GASTROINTESTINAL DYSFUNCTION VIP, FABP2, SI ALDH1A1 444/4885CYP1A2 530/4885CYP2C9 1619/4885
US-20140303211-A1 COMPOSITIONS CONTAINING OPIOID ANTAGONISTS OPRK1, OPRL1, OPRM1 ALDH1A1 1750/4885CYP1A2 157/4885CYP2C9 173/4885
US-20150150819-A1 COMPOSITIONS CONTAINING OPIOID ANTAGONISTS OPRK1, OPRM1, OPRD1 ALDH1A1 2312/4885CYP1A2 102/4885CYP2C9 87/4885
US-20040209857-A1 Lactam derivatives and methods of their use MRPL21, SI, PEPD ALDH1A1 618/4885CYP1A2 100/4885CYP2C9 12/4885
US-20050054630-A1 Fused bicyclic carboxamide derivatives and methods of their use PAICS, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CPS1 ALDH1A1 1541/4885CYP1A2 273/4885CYP2C9 58/4885
US-20140186951-A1 NOVEL OPIOID ANTAGONISTS OPRK1, OPRM1, OPRL1 ALDH1A1 761/4885CYP1A2 474/4885CYP2C9 720/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.