Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | LIPE | Q05469 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5865561 | 0.86 | PTGS1 (0.42) | PTGS2PTGS1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL28869838 | 0.86 | PDPK1 (0.45) | PDPK1PTGS1HSD11B1CYP1A2RAB9A | |
| SCHEMBL1115174 | 0.84 | HSD11B1 (0.39) | PTGS2PDPK1PTGS1HSD11B1AKT1 | |
| SCHEMBL5865601 | 0.83 | PTGS2 (0.44) | PTGS2PDPK1PTGS1CYP3A4CYP2C9 | |
| SCHEMBL5205230 | 0.83 | LMNA (0.46) | PTGS2PTGS1CYP1A2CYP3A4GABRP | |
| SCHEMBL5202264 | 0.82 | PTGS2 (0.43) | PTGS2PTGS1SMN1; SMN2GABRPGABRD | |
| SCHEMBL5865366 | 0.82 | PTGS2 (0.43) | PTGS2PTGS1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5204715 | 0.81 | PTGS2 (0.58) | PTGS2PTGS1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6885231 | 0.81 | PTGS2 (0.58) | PTGS2PTGS1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5201440 | 0.81 | PTGS2 (0.49) | PTGS2PDPK1PTGS1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565456-B1 | 1,2,4-TRIAZOLE DERIVATIVE, METHOD FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | CJ CHEILJEDANG CORP (KR) | 2008-10-01 | — | — | EP | disclosed |
| EP-1565456-B1 | 1,2,4-TRIAZOLE DERIVATIVE, METHOD FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | CJ CHEILJEDANG CORP (KR) | 2008-10-01 | — | — | EP | disclosed |
| EP-1565456-A4 | 1,2,4-TRIAZOLE DERIVATIVE, METHOD FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | CJ CORP (KR) | 2007-08-01 | — | — | EP | disclosed |
| US-7230010-B2 | 1,2,4-triazole derivative, method for preparing the same, and pharmaceutical composition containing the same | CJ CORP. (KR) | 2007-06-12 | — | — | US | disclosed |
| US-7230010-B2 | 1,2,4-triazole derivative, method for preparing the same, and pharmaceutical composition containing the same | CJ CORP. (KR) | 2007-06-12 | — | — | US | disclosed |
| US-7230010-B2 | 1,2,4-triazole derivative, method for preparing the same, and pharmaceutical composition containing the same | CJ CORP. (KR) | 2007-06-12 | — | — | US | disclosed |
| EP-1565456-A1 | 1,2,4-TRIAZOLE DERIVATIVE, METHOD FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | CJ Corporation (KR) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004048367-A1 | 1,2,4-TRIAZOLE DERIVATIVE, METHOD FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | CJ CORPORATION (KR) | 2004-06-10 | — | — | WO | disclosed |
| US-20040106612-A1 | 1,2,4-Triazole derivative, method for preparing the same, and pharmaceutical composition containing the same | CJ CHEILJEDANG CORPORATION (KR) | 2004-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106612-A1 | 1,2,4-Triazole derivative, method for preparing the same, and pharmaceutical composition containing the same | NAT1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CYP1B1 | PTGS2 3173/4885PDPK1 1298/4885PTGS1 1278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.