Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 5/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4671309 | 0.83 | MGLL (0.43) | LMNATP53MAPTL3MBTL1MEN1 | |
| SCHEMBL8149178 | 0.82 | MGLL (0.48) | LMNATP53MAPTL3MBTL1MEN1 | |
| SCHEMBL8140788 | 0.81 | ALDH1A1 (0.48) | LMNATP53MAPTL3MBTL1MEN1 | |
| SCHEMBL4674725 | 0.80 | LMNA (0.61) | LMNATP53MAPTL3MBTL1MEN1 | |
| SCHEMBL4671256 | 0.80 | MGLL (0.46) | LMNATP53MAPTL3MBTL1MEN1 | |
| SCHEMBL7325935 | 0.80 | MGLL (0.46) | LMNATP53MAPTL3MBTL1MEN1 | |
| SCHEMBL8105525 | 0.79 | MGLL (0.43) | LMNATP53MAPTL3MBTL1MEN1 | |
| SCHEMBL8111407 | 0.79 | LMNA (0.46) | LMNATP53MAPTL3MBTL1MEN1 | |
| SCHEMBL8109739 | 0.79 | MGLL (0.45) | LMNATP53MAPTL3MBTL1MEN1 | |
| SCHEMBL8150423 | 0.79 | LMNA (0.45) | LMNATP53MAPTL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |