Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | PKM | P14618 | 3/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PKLR | P30613 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4675636 | 0.88 | PKM (0.64) | MAPTPKMHDAC3HDAC4HDAC1 | |
| SCHEMBL4672292 | 0.79 | HPGD (0.50) | MAPTPKMHSD17B10MEN1KMT2A | |
| SCHEMBL14143438 | 0.75 | ADRB3 (0.44) | MAPTPKMPOLBTDP1PGR | |
| SCHEMBL4672139 | 0.75 | CYP4F2 (0.41) | MAPTPKMHDAC3HDAC1HDAC2 | |
| SCHEMBL14143276 | 0.73 | PGR (0.48) | MAPTPKMPOLBPGRLMNA | |
| SCHEMBL4670404 | 0.71 | ADRB2 (0.49) | MAPTPKMHDAC3HDAC4HDAC1 | |
| SCHEMBL29586898 | 0.71 | MAPT (0.44) | MAPTPKMPGRLMNACYP2D6 | |
| SCHEMBL5839879 | 0.70 | ESR1 (0.56) | HDAC3HDAC1HDAC2OPRK1 | |
| SCHEMBL1064265 | 0.69 | CYP4F2 (0.44) | HDAC3HDAC1HDAC2POLBMEN1 | |
| SCHEMBL430182 | 0.69 | CYP4F2 (0.50) | HDAC3HDAC1HDAC2POLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054881-B1 | NOVEL SULFONAMIDE SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA-3 ADRENORECEPTOR AGONISTS | BAYER CORP (US) | 2008-07-30 | — | — | EP | disclosed |