Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 12/20 | 0.46 |
| ▸ | MMP2 | P08253 | 12/20 | 0.46 |
| ▸ | MMP1 | P03956 | 3/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4671682 | 0.90 | MMP2 (0.43) | MMP3MMP2CCNT1CDK9LMNA | |
| SCHEMBL4671681 | 0.90 | MMP2 (0.43) | MMP3MMP2CCNT1CDK9LMNA | |
| SCHEMBL4674941 | 0.87 | MMP1 (0.48) | MMP3MMP2MMP1CCNT1CDK9 | |
| SCHEMBL4675047 | 0.85 | MMP1 (0.48) | MMP3MMP2MMP1HCRTR1HCRTR2 | |
| SCHEMBL4671598 | 0.83 | MMP2 (0.41) | MMP3MMP2CCNT1CDK9HCRTR1 | |
| SCHEMBL4676814 | 0.79 | MMP3 (0.51) | MMP3MMP2MMP1MMP7MMP13 | |
| SCHEMBL4674089 | 0.78 | MMP2 (0.43) | MMP3MMP2CCNT1CDK9LMNA | |
| SCHEMBL4674088 | 0.78 | MMP2 (0.43) | MMP3MMP2CCNT1CDK9LMNA | |
| SCHEMBL4675090 | 0.75 | ADAM17 (0.50) | MMP3MMP2MMP1MMP13LMNA | |
| SCHEMBL4676634 | 0.73 | LMNA (0.43) | MMP3MMP2MMP1MMP7MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |
| US-6143744-A | Sulfamide-metalloprotease inhibitors | SYNTEX (U.S.A.) INC. (US) | 2000-11-07 | — | — | US | disclosed |
| US-6130220-A | ENZYME INHIBITORS | SYNTEX (USA) INC. (US) | 2000-10-10 | — | — | US | disclosed |
| US-5998412-A | ANTIARTHRITIC AGENTS; OSTEOPOROSIS | SYNTEX (U.S.A.) INC. (US) | 1999-12-07 | — | — | US | disclosed |