SCHEMBL4676316

SCHEMBL4676316

CC(C)(C)OC(=O)NN1CCC(NC(=O)OCc2ccccc2)C1=O

nearest known ligand 0.53

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CTSK P43235 2/20 0.53
CASP3 P42574 1/20 0.47
ALDH1A1 P00352 1/20 0.45
GAA P10253 1/20 0.45
CTSL P07711 2/20 0.44
SYK P43405 1/20 0.44
CTSB P07858 1/20 0.44
CASP1 P29466 1/20 0.44
KMT2A Q03164 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
PREP P48147 2/20 0.43
NAAA Q02083 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4678408 1.00 CTSK (0.53) CTSKCASP3ALDH1A1GAACTSL
SCHEMBL4676319 1.00 CTSK (0.53) CTSKCASP3ALDH1A1GAACTSL
SCHEMBL7381037 0.84 CTSL (0.49) CTSLSYKKMT2AL3MBTL1PREP
SCHEMBL3735969 0.84 CASP3 (0.47) CTSKCASP3ALDH1A1GAACTSL
SCHEMBL7383776 0.84 CTSL (0.49) CTSLSYKKMT2AL3MBTL1PREP
SCHEMBL5729512 0.83 GAA (0.47) CTSKGAA
SCHEMBL6620628 0.82 KMT2A (0.47) CTSKCASP3CTSLCTSBKMT2A
SCHEMBL6620619 0.82 KMT2A (0.47) CTSKCASP3CTSLCTSBKMT2A
SCHEMBL4869543 0.81 CTSK (0.47) CTSKCASP3CTSLCTSB
SCHEMBL4861261 0.81 CTSK (0.47) CTSKCASP3CTSLCTSB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1975153-A2 Protease inhibitors Prozymex A/S (DK) 2008-10-01 EP disclosed
EP-1975153-A2 Protease inhibitors Prozymex A/S (DK) 2008-10-01 EP disclosed
EP-1633702-B1 PROTEASE INHIBITORS PROZYMEX AS (DK) 2008-07-02 EP disclosed
EP-1633702-B1 PROTEASE INHIBITORS PROZYMEX AS (DK) 2008-07-02 EP disclosed
US-20070155803-A1 Protease inhibitors PROZYMEX A/S (DK) 2007-07-05 US disclosed
US-20070155803-A1 Protease inhibitors PROZYMEX A/S (DK) 2007-07-05 US disclosed
US-20070155803-A1 Protease inhibitors PROZYMEX A/S (DK) 2007-07-05 US disclosed
EP-1633702-A1 PROTEASE INHIBITORS Prozymex A/S (DK) 2006-03-15 EP disclosed
WO-2004106289-A1 PROTEASE INHIBITORS PROZYMEX A/S (DK) 2004-12-09 WO disclosed
WO-2004106289-A1 PROTEASE INHIBITORS PROZYMEX A/S (DK) 2004-12-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070155803-A1 Protease inhibitors DPP7, DPP9, DPP3 CTSK 5/4885CASP3 266/4885ALDH1A1 2713/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.