Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR4 | P46093 | 7/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.34 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL467878 | 0.99 | GPR4 (0.46) | GPR4CTSKLTA4HKDM4EALDH1A1 | |
| SCHEMBL467664 | 0.89 | LTA4H (0.48) | LTA4HKDM4EALDH1A1LMNATSHR | |
| SCHEMBL27919676 | 0.86 | GPR4 (0.37) | GPR4CTSKL3MBTL3L3MBTL1GRIN2B | |
| SCHEMBL28823410 | 0.86 | GPR4 (0.37) | GPR4CTSKL3MBTL3L3MBTL1GRIN2B | |
| SCHEMBL22189937 | 0.85 | GPR4 (0.39) | GPR4CTSKL3MBTL3L3MBTL1GRIN2B | |
| SCHEMBL27901899 | 0.85 | GPR4 (0.39) | GPR4CTSKL3MBTL3L3MBTL1GRIN2B | |
| SCHEMBL467544 | 0.81 | ALDH1A1 (0.38) | LTA4HKDM4EALDH1A1LMNATSHR | |
| SCHEMBL28038872 | 0.81 | L3MBTL3 (0.56) | KDM4EALDH1A1TSHRL3MBTL3L3MBTL1 | |
| SCHEMBL467818 | 0.79 | ALDH1A1 (0.34) | GPR4KDM4EALDH1A1LMNATSHR | |
| SCHEMBL28823415 | 0.79 | L3MBTL3 (0.61) | L3MBTL3L3MBTL1MBTD1TP53BP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387395-A1 | AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER | Rigel Pharmaceuticals, Inc. (US) | 2011-11-23 | — | — | EP | disclosed |
| US-8040491-B2 | Exposure method, substrate stage, exposure apparatus, and device manufacturing method | NIKON CORPORATION (JP) | 2011-10-18 | — | — | US | disclosed |