SCHEMBL467677

SCHEMBL467677

CO[SiH](OC)C(Br)c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.38
CES2 O00748 1/20 0.37
CES1 P23141 1/20 0.37
TRPA1 O75762 1/20 0.37
THRB P10828 1/20 0.36
TAAR1 Q96RJ0 1/20 0.34
MEN1 O00255 2/20 0.34
MAPT P10636 2/20 0.34
MAPK1 P28482 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
DPP4 P27487 2/20 0.33
F2 P00734 1/20 0.33
TSHR P16473 1/20 0.33
CA4 P22748 1/20 0.33
RAB9A P51151 1/20 0.33
HPGD P15428 1/20 0.33
EPHX1 P07099 1/20 0.32
ALDH1A1 P00352 1/20 0.32
ACP3 P15309 1/20 0.32
IDO1 P14902 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10568864 0.76 KMT2A (0.40) KMT2ATHRBTAAR1MEN1MAPT
SCHEMBL296207 0.76 KMT2A (0.40) KMT2ATHRBTAAR1MEN1MAPT
SCHEMBL19809329 0.74 KMT2A (0.43) KMT2AMEN1MAPK1TSHRALDH1A1
SCHEMBL63868 0.73 DPP4 (0.44) KMT2ATAAR1DPP4F2ALDH1A1
SCHEMBL2202411 0.73 TSHR (0.44) KMT2AMEN1MAPTMAPK1SMN1; SMN2
SCHEMBL3337870 0.73 KMT2A (0.38) KMT2ATHRBMEN1MAPTMAPK1
SCHEMBL9716579 0.71 KMT2A (0.36) KMT2ATHRBTAAR1MEN1MAPT
SCHEMBL467831 0.70 CES2 (0.42) CES2CES1TRPA1TAAR1MAPK1
SCHEMBL9716570 0.70 HKDC1 (0.43) KMT2ATRPA1TAAR1MEN1MAPT
SCHEMBL705765 0.70 LMNA (0.43) KMT2ATRPA1TAAR1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9249262-B2 Curable organic polymer and method for production thereof, and curable composition containing the same KANEKA CORPORATION (JP) 2016-02-02 US disclosed
CN-102947317-B Method for producing alkoxyhydrogensilanes KANEKA CORP. (JP) 2016-01-20 CN disclosed
EP-2386561-B1 Methods for producing alkoxyhydrosilanes KANEKA CORP (JP) 2016-01-13 EP disclosed
EP-2392600-B1 Polymer having a reactive silicon-containing group, methods for its preparation and a curable composition comprising the polymer KANEKA CORP (JP) 2015-12-23 EP disclosed
EP-2586784-B1 METHOD FOR PRODUCING ALKOXY HYDROSILANE KANEKA CORP (JP) 2015-12-09 EP disclosed
CN-102947318-B The preparation method of alkoxyl group hydrogen silane KANEKA CORP. (JP) 2015-10-21 CN disclosed
EP-2586783-B1 METHOD FOR PRODUCING ALKOXY HYDROSILANE KANEKA CORP (JP) 2015-08-05 EP disclosed
CN-102174188-B Polymer comprising reactive silicon group KANEKA CORP 2014-11-26 CN disclosed
EP-2586783-A1 METHOD FOR PRODUCING ALKOXY HYDROSILANE Kaneka Corporation (JP) 2013-05-01 EP disclosed
EP-2586784-A1 METHOD FOR PRODUCING ALKOXY HYDROSILANE Kaneka Corporation (JP) 2013-05-01 EP disclosed
US-20120196981-A1 METHOD FOR PRODUCING a-HETERO-SUBSTITUTED ALKYLHALOHYDROSILANE AND USE THEREOF KANEKACORPORATION (JP) 2012-08-02 US disclosed
EP-2392600-A1 Polymer having a reactive silicon-containing group, methods for its preparation and a curable composition comprising the polymer Kaneka Corporation (JP) 2011-12-07 EP disclosed
EP-2386561-A1 Methods for producing alkoxyhydrosilanes Kaneka Corporation (JP) 2011-11-16 EP disclosed
US-8039142-B2 Battery case SONY CORPORATION (JP) 2011-10-18 US disclosed
CN-102174188-A Polymer comprising reactive silcon group KANEKA CORP 2011-09-07 CN disclosed
US-20110207886-A1 Method for Producing a-hereto-Substituted Alkylhalohydrosilane and Use Thereof KANEKA CORPORATION (JP) 2011-08-25 US disclosed
CN-102140108-A Method for producing alkylhalohydrosilane compound KANEKA CORP 2011-08-03 CN disclosed
CN-102037000-A Process for producing alpha-hetero-substituted alkylhalohydrosilanes and use thereof KANEKA CORP 2011-04-27 CN disclosed
EP-2308884-A1 METHOD FOR PRODUCING -HETERO-SUBSTITUTED ALKYLHALOHYDROSILANE AND USE THEREOF Kaneka Corporation (JP) 2011-04-13 EP disclosed
US-20090247712-A1 CURABLE ORGANIC POLYMER AND METHOD FOR PRODUCTION THEREOF, AND CURABLE COMPOSITION CONTAINING THE SAME KANEKA CORPORATION (JP) 2009-10-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120196981-A1 METHOD FOR PRODUCING a-HETERO-SUBSTITUTED ALKYLHALOHYDROSILANE AND USE THEREOF ARSA, HACL2, AS3MT KMT2A 712/4885CES2 920/4885CES1 2426/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.