Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 6/20 | 0.41 |
| ▸ | MMP3 | P08254 | 6/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4671598 | 0.89 | MMP2 (0.41) | MMP2MMP3CCNT1CDK9GPR119 | |
| SCHEMBL4674088 | 0.87 | MMP2 (0.43) | MMP2MMP3CCNT1CDK9PTGDR | |
| SCHEMBL4674089 | 0.87 | MMP2 (0.43) | MMP2MMP3CCNT1CDK9PTGDR | |
| SCHEMBL7465557 | 0.77 | LMNA (0.43) | MMP2MMP3CCNT1CDK9GPR119 | |
| SCHEMBL4671682 | 0.76 | MMP2 (0.43) | MMP2MMP3CCNT1CDK9KDM4E | |
| SCHEMBL4671681 | 0.76 | MMP2 (0.43) | MMP2MMP3CCNT1CDK9KDM4E | |
| SCHEMBL4676047 | 0.72 | MMP3 (0.46) | MMP2MMP3CCNT1CDK9THRB | |
| SCHEMBL4675047 | 0.71 | MMP1 (0.48) | MMP2MMP3ADAMTS5MMP14SLC18A3 | |
| SCHEMBL4671335 | 0.69 | LMNA (0.42) | MMP2MMP3KDM4ETHRBMAPT | |
| SCHEMBL4674941 | 0.69 | MMP1 (0.48) | MMP2MMP3CCNT1CDK9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | claimed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | claimed |