SCHEMBL4677382

SCHEMBL4677382

CC[C@@H](N)C(=O)NNC(=O)N[C@@H](CCc1ccccc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KISS1R Q969F8 8/20 0.45
GHSR Q92847 3/20 0.44
F10 P00742 2/20 0.42
ANPEP P15144 2/20 0.41
IL1RN P18510 2/20 0.41
ERAP2 Q6P179 2/20 0.41
ERAP1 Q9NZ08 2/20 0.41
LNPEP Q9UIQ6 1/20 0.41
CTSC P53634 1/20 0.41
MMP2 P08253 1/20 0.40
MMP9 P14780 1/20 0.40
MMP8 P22894 1/20 0.40
CTSL P07711 1/20 0.40
CTSS P25774 1/20 0.40
CTSK P43235 1/20 0.40
KLKB1 P03952 1/20 0.40
KLK1 P06870 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4677415 1.00 KISS1R (0.45) KISS1RGHSRF10ANPEPIL1RN
SCHEMBL4683795 0.85 MMP2 (0.51) KISS1RGHSRF10MMP2MMP9
SCHEMBL4679584 0.85 MMP2 (0.51) KISS1RGHSRF10MMP2MMP9
SCHEMBL4677756 0.84 GHSR (0.62) KISS1RGHSRANPEPIL1RNERAP2
SCHEMBL4677349 0.84 GHSR (0.62) KISS1RGHSRANPEPIL1RNERAP2
SCHEMBL4677370 0.83 MMP9 (0.51) GHSRF10MMP2MMP9MMP8
SCHEMBL4680997 0.81 KISS1R (0.53) KISS1RGHSRIL1RNERAP2ERAP1
SCHEMBL4676538 0.81 KISS1R (0.53) KISS1RGHSRIL1RNERAP2ERAP1
SCHEMBL4682112 0.79 FCER2 (0.51) KISS1RERAP2ERAP1LNPEPCTSC
SCHEMBL4676548 0.79 KISS1R (0.49) KISS1RGHSRIL1RNERAP2ERAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1633702-B1 PROTEASE INHIBITORS PROZYMEX AS (DK) 2008-07-02 EP claimed
US-20070155803-A1 Protease inhibitors PROZYMEX A/S (DK) 2007-07-05 US claimed
EP-1975153-A2 Protease inhibitors Prozymex A/S (DK) 2008-10-01 EP disclosed
EP-1633702-B1 PROTEASE INHIBITORS PROZYMEX AS (DK) 2008-07-02 EP disclosed
US-20070155803-A1 Protease inhibitors PROZYMEX A/S (DK) 2007-07-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070155803-A1 Protease inhibitors DPP7, DPP9, DPP3 KISS1R 1337/4885GHSR 344/4885F10 4636/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.