Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.68 |
| ▸ | HTR3B | O95264 | 2/20 | 0.68 |
| ▸ | HTR3A | P46098 | 2/20 | 0.68 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.68 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | NMT2 | O60551 | 1/20 | 0.44 |
| ▸ | NMT1 | P30419 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4677474 | 0.86 | HTR3E (0.51) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8096357 | 0.82 | ALDH1A1 (0.56) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL10784335 | 0.82 | HTR4 (0.69) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL29206560 | 0.80 | ALDH1A1 (0.51) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL30053987 | 0.80 | ALDH1A1 (0.51) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL2078270 | 0.77 | KDM4E (0.55) | SLC6A4ALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL784795 | 0.77 | KDM4E (0.81) | SLC6A4ALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL6616994 | 0.77 | KDM4E (0.55) | SLC6A4ALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL6616991 | 0.77 | KDM4E (0.55) | SLC6A4ALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL30323082 | 0.76 | CES2 (0.52) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |
| US-5998412-A | ANTIARTHRITIC AGENTS; OSTEOPOROSIS | SYNTEX (U.S.A.) INC. (US) | 1999-12-07 | — | — | US | disclosed |