Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | KDM1A | O60341 | 3/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.46 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28809778 | 0.82 | HTR4 (0.60) | HTR4ALDH1A1KMT2AKDM1AHTR3E | |
| SCHEMBL29753960 | 0.82 | HTR4 (0.60) | HTR4ALDH1A1KMT2AKDM1AHTR3E | |
| SCHEMBL4677480 | 0.82 | HTR3E (0.68) | HTR4ALDH1A1KMT2ASLC6A4SMN1; SMN2 | |
| SCHEMBL28809209 | 0.81 | HTR4 (0.59) | HTR4ALDH1A1KMT2AKDM1ATDO2 | |
| SCHEMBL29754034 | 0.81 | HTR4 (0.59) | HTR4ALDH1A1KMT2AKDM1ATDO2 | |
| SCHEMBL23533891 | 0.79 | HTR4 (0.56) | HTR4ALDH1A1KMT2AKDM1ATDO2 | |
| SCHEMBL29753901 | 0.79 | HTR4 (0.56) | HTR4ALDH1A1KMT2AKDM1ATDO2 | |
| SCHEMBL10778966 | 0.78 | SIGMAR1 (0.62) | ALDH1A1KMT2A | |
| SCHEMBL29754113 | 0.77 | DYRK1A (0.70) | HTR4KDM1A | |
| SCHEMBL28810251 | 0.77 | DYRK1A (0.70) | HTR4KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150505-B1 | 3-INDOLECARBOXAMIDE COMPOUNDS | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1987-04-01 | — | — | EP | disclosed |
| EP-0144986-B1 | INDOLE-3-CARBOXAMIDE DERIVATIVES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1987-03-04 | — | — | EP | disclosed |
| US-4616009-A | PSYCHOLOGICAL DISORDERS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1986-10-07 | — | — | US | disclosed |
| US-4581355-A | HYPOTENSIVE AGENTS, LIPOXYGENASE INHIBITORS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1986-04-08 | — | — | US | disclosed |
| EP-0150505-A2 | 3-Indolecarboxamide compounds | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1985-08-07 | — | — | EP | disclosed |
| EP-0144986-A2 | Indole-3-carboxamide derivatives | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1985-06-19 | — | — | EP | disclosed |