Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | AGXT | P21549 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10878681 | 0.82 | AGXT (0.42) | LOXL2AGXTKDM4EFLT3SMN1; SMN2 | |
| SCHEMBL3541730 | 0.82 | ALDH1A1 (0.49) | LOXL2AGXTKDM4ESMN1; SMN2POLB | |
| SCHEMBL28720245 | 0.81 | ALDH1A1 (0.43) | LOXL2AGXTKDM4ESMN1; SMN2POLB | |
| SCHEMBL16534423 | 0.79 | FAAH (0.44) | LOXL2AGXTKDM4EMAOBMEN1 | |
| SCHEMBL28712168 | 0.79 | ALDH1A1 (0.42) | LOXL2AGXTKDM4ESMN1; SMN2HPGD | |
| SCHEMBL4624720 | 0.78 | LOXL2 (0.52) | LOXL2AGXTKDM4EFLT3SMN1; SMN2 | |
| SCHEMBL18762013 | 0.78 | POLB (0.47) | LOXL2AGXTKDM4EFLT3POLB | |
| SCHEMBL5719086 | 0.78 | AGXT (0.44) | LOXL2AGXTKDM4EFLT3SMN1; SMN2 | |
| SCHEMBL29424653 | 0.77 | KDM4E (0.41) | LOXL2AGXTKDM4ESMN1; SMN2POLB | |
| SCHEMBL28167314 | 0.76 | AGXT (0.43) | LOXL2AGXTKDM4EFLT3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020183011-A1 | HTR1D INHIBITORS AND USES THEREOF IN THE TREATMENT OF CANCER | INSTITUT CURIE (FR) | 2020-09-17 | — | — | WO | disclosed |
| EP-1594864-B1 | BENZOFURAN OXYETHYLAMINES SERVING AS ANTIDEPRESSANT DRUGS AND ANXIOLYTIC DRUGS | MERCK PATENT GMBH (DE) | 2008-10-22 | — | — | EP | disclosed |
| EP-1594864-B1 | BENZOFURAN OXYETHYLAMINES SERVING AS ANTIDEPRESSANT DRUGS AND ANXIOLYTIC DRUGS | MERCK PATENT GMBH (DE) | 2008-10-22 | — | — | EP | disclosed |
| US-7425574-B2 | e.g. 4-{2-[4-(5-cyano-1H-indol-3-yl)butylamino]ethoxy}benzofuran-2-carboxylic acid methyl ester; serotonin 5 HT1A and 5HT1D receptors agonist and antagonist, serotonin reuptake inhibitor; neuroleptic and hypotensive agent; | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-09-16 | — | — | US | disclosed |
| US-7425574-B2 | e.g. 4-{2-[4-(5-cyano-1H-indol-3-yl)butylamino]ethoxy}benzofuran-2-carboxylic acid methyl ester; serotonin 5 HT1A and 5HT1D receptors agonist and antagonist, serotonin reuptake inhibitor; neuroleptic and hypotensive agent; | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-09-16 | — | — | US | disclosed |
| US-20060084693-A1 | Benzofuran oxyethylamines as antidepressants and anxiolytics | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-04-20 | — | — | US | disclosed |
| US-20060084693-A1 | Benzofuran oxyethylamines as antidepressants and anxiolytics | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-04-20 | — | — | US | disclosed |
| WO-2004074281-A8 | BENZOFURAN OXYETHYLAMINES SERVING AS ANTIDEPRESSANT DRUGS AND ANXIOLYTIC DRUGS | MERCK PATENT GMBH (DE) | 2005-11-17 | — | — | WO | disclosed |
| EP-1594864-A1 | BENZOFURAN OXYETHYLAMINES SERVING AS ANTIDEPRESSANT DRUGS AND ANXIOLYTIC DRUGS | MERCK PATENT GmbH (DE) | 2005-11-16 | — | — | EP | disclosed |
| EP-1594864-A1 | BENZOFURAN OXYETHYLAMINES SERVING AS ANTIDEPRESSANT DRUGS AND ANXIOLYTIC DRUGS | MERCK PATENT GmbH (DE) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004074281-A1 | BENZOFURAN OXYETHYLAMINES SERVING AS ANTIDEPRESSANT DRUGS AND ANXIOLYTIC DRUGS | MERCK PATENT GMBH (DE) | 2004-09-02 | — | — | WO | disclosed |
| WO-2004074281-A1 | BENZOFURAN OXYETHYLAMINES SERVING AS ANTIDEPRESSANT DRUGS AND ANXIOLYTIC DRUGS | MERCK PATENT GMBH (DE) | 2004-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084693-A1 | Benzofuran oxyethylamines as antidepressants and anxiolytics | HTR1D, HTR1A, HTR1F | LOXL2 3284/4885AGXT 2793/4885HTR1B 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.