SCHEMBL4681001

SCHEMBL4681001

COc1cn(C(c2ccccc2)c2ccccc2)c(=O)o1

nearest known ligand 0.42

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
FAAH O00519 10/20 0.42
GAA P10253 1/20 0.42
CYP19A1 P11511 2/20 0.35
PLA2G4A P47712 1/20 0.35
MGLL Q99685 3/20 0.35
CYP2C9 P11712 5/20 0.34
CYP3A4 P08684 2/20 0.34
CYP2D6 P10635 2/20 0.34
CDC25A P30304 1/20 0.33
CDC25B P30305 1/20 0.33
CYP2C19 P33261 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4679478 0.86 FAAH (0.51) FAAHMGLLCYP2D6
SCHEMBL4676274 0.86 FAAH (0.51) FAAHMGLLCYP2D6
SCHEMBL6759635 0.84 GAA (0.40) FAAHGAACYP3A4
SCHEMBL6761258 0.83 GAA (0.39) FAAHGAACYP19A1MGLLCDC25B
SCHEMBL6760099 0.83 GAA (0.41) FAAHGAACYP19A1MGLLCYP3A4
SCHEMBL6760443 0.82 GAA (0.41) FAAHGAAMGLL
SCHEMBL6759586 0.81 GAA (0.38) GAACYP19A1PLA2G4A
SCHEMBL4678103 0.72 FAAH (0.43) FAAHMGLLCYP2D6
SCHEMBL4678109 0.72 FAAH (0.43) FAAHMGLLCYP2D6
SCHEMBL6760765 0.71 KDM4E (0.41) FAAHGAAMGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0945448-B1 5-ALKOXY-2(3H)-OXAZOLONE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF UBE INDUSTRIES (JP) 2008-11-26 EP claimed
US-6414160-B1 REACTING 5-ALKOXY-2(3H)OXAZOLONE COMPOUND WITH ALDEHYDE COMPOUND IN PRESENCE OF LEWIS ACID CATALYST UBE INDUSTRIES, LTD. (JP) 2002-07-02 US claimed
EP-1000937-A1 PROCESS FOR PRODUCING 4-ALKOXYCARBONYL-2-OXAZOLIDINONE COMPOUNDS UBE INDUSTRIES LIMITED (JP) 2000-05-17 EP claimed
US-6020496-A 5-alkoxy-2(3H)-oxazolone compounds and process for preparing the same UBE INDUSTRIES, LTD. (JP) 2000-02-01 US claimed
EP-0945448-A1 5-ALKOXY-2(3H)-OXAZOLONE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF UBE INDUSTRIES, LTD. (JP) 1999-09-29 EP claimed
EP-0945448-B1 5-ALKOXY-2(3H)-OXAZOLONE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF UBE INDUSTRIES (JP) 2008-11-26 EP disclosed
US-6723860-B2 7a-alkoxy-4H-pyrano[3,2-d]-oxazol-2(3H)-one and process for producing the same UBE INDUSTRIES, LTD. (JP) 2004-04-20 US disclosed
EP-1207162-B1 7a-alkoxy-4H-pyrano-[3,2-d]-oxazol-2(3H)-one and process for producing the same UBE INDUSTRIES (JP) 2004-02-25 EP disclosed
US-6414160-B1 REACTING 5-ALKOXY-2(3H)OXAZOLONE COMPOUND WITH ALDEHYDE COMPOUND IN PRESENCE OF LEWIS ACID CATALYST UBE INDUSTRIES, LTD. (JP) 2002-07-02 US disclosed
US-20020072612-A1 7a-alkoxy-4H-pyrano [3,2-d] -oxazol-2 (3H) -one and process for producing the same UBE INDUSTRIES, LTD. (JP) 2002-06-13 US disclosed
EP-1207162-A1 7a-alkoxy-4H-pyrano-[3,2-d]-oxazol-2(3H)-one and process for producing the same Ube Industries, Ltd. (JP) 2002-05-22 EP disclosed
EP-1000937-A1 PROCESS FOR PRODUCING 4-ALKOXYCARBONYL-2-OXAZOLIDINONE COMPOUNDS UBE INDUSTRIES LIMITED (JP) 2000-05-17 EP disclosed
US-6020496-A 5-alkoxy-2(3H)-oxazolone compounds and process for preparing the same UBE INDUSTRIES, LTD. (JP) 2000-02-01 US disclosed
EP-0945448-A1 5-ALKOXY-2(3H)-OXAZOLONE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF UBE INDUSTRIES, LTD. (JP) 1999-09-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020072612-A1 7a-alkoxy-4H-pyrano [3,2-d] -oxazol-2 (3H) -one and process for producing the same ACSL1, ACSL4, ACSL3 FAAH 183/4885GAA 2791/4885CYP19A1 872/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.