Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRB | P23467 | 6/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | CCR3 | P51677 | 2/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3569181 | 0.85 | PTPRB (0.71) | PTPRBCCR3 | |
| SCHEMBL468091 | 0.85 | PTPRB (0.71) | PTPRBCCR3 | |
| SCHEMBL468090 | 0.85 | PTPRB (0.71) | PTPRBCCR3 | |
| SCHEMBL27883944 | 0.85 | PTPRB (0.71) | PTPRBCCR3 | |
| SCHEMBL468277 | 0.84 | MMP8 (0.44) | PTPRBMMP2CCR3MEN1KMT2A | |
| SCHEMBL1287147 | 0.83 | OPRM1 (0.52) | PTPRBCCR3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3694833 | 0.82 | MEN1 (0.45) | PTPRBMMP2CCR3MEN1KMT2A | |
| SCHEMBL19837047 | 0.81 | ALDH1A1 (0.39) | PTPRBMMP2CCR3MEN1KMT2A | |
| SCHEMBL16060603 | 0.81 | MMP2 (0.40) | PTPRBMMP2CCR3MEN1KMT2A | |
| SCHEMBL16059632 | 0.81 | LMNA (0.39) | CCR3MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451279-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR PREVENTING METASTASIS OF CANCER CELLS | Akebia Therapeutics Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| EP-2385763-A1 | METHODS FOR TREATING VASCULAR LEAK SYNDROME | Akebia Therapeutics Inc. (US) | 2011-11-16 | — | — | EP | disclosed |
| US-20110253725-A1 | MULTI-PORT BEVERAGE AND FOOD CONTAINERS | KILLIAN WILLIAM | 2011-10-20 | — | — | US | disclosed |
| WO-2011005330-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR PREVENTING METASTASIS OF CANCER CELLS | AKEBIA THERAPEUTICS INC. (US) | 2011-01-13 | — | — | WO | disclosed |
| WO-2010081172-A1 | METHODS FOR TREATING VASCULAR LEAK SYNDROME | AKEBIA THERAPEUTICS INC. (US) | 2010-07-15 | — | — | WO | disclosed |