Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.69 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.69 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.69 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | KDM5C | P41229 | 3/20 | 0.45 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.45 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.45 |
| ▸ | KDM6B | O15054 | 2/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.45 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL518643 | 0.96 | LMNA (0.75) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL93822 | 0.96 | LMNA (0.75) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL468618 | 0.92 | LMNA (0.69) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL468630 | 0.92 | LMNA (0.69) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL21219028 | 0.92 | LMNA (0.69) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL468649 | 0.92 | LMNA (0.69) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL2572722 | 0.92 | LMNA (0.69) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL17077298 | 0.92 | LMNA (0.69) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL295052 | 0.92 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL987258 | 0.92 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1SLC15A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9282735-B2 | Use of EDDS and calcium ions as enchancers of molluscicidal activity | INNOSPEC LIMITED (GB) | 2016-03-15 | — | — | US | claimed |
| US-20150237850-A1 | COMPOSITION, METHOD AND USE | W. NEUDORFF GMBH KG (DE) | 2015-08-27 | — | — | US | claimed |
| EP-2389065-B1 | USE OF EDDS AND CALCIUM IONS AS ENHANCERS OF MOLLUSCICIDAL ACTIVITY | INNOSPEC LTD (GB) | 2015-08-19 | — | — | EP | claimed |
| US-9044009-B2 | Use of EDDS and calcium ions as enhancers of molluscicidal activity | W.NEUDORFF GMBH KG (DE) | 2015-06-02 | — | — | US | claimed |
| US-20120027832-A1 | USE OF EDDS AND CALCIUM IONS AS ENHANCERS OF MOLLUSCICIDAL ACTIVITY | W. NEUDORFF GMBH KG (DE) | 2012-02-02 | — | — | US | claimed |
| EP-2389065-A2 | USE OF EDDS AND CALCIUM IONS AS ENHACERS OF MOLLUSCICIDAL ACTIVITY | Innospec Limited (GB) | 2011-11-30 | — | — | EP | claimed |
| WO-2010084361-A2 | COMPOSITION, METHOD AND USE | INNOSPEC LIMITED (GB) | 2010-07-29 | — | — | WO | claimed |
| US-20020136751-A1 | Naturally occurring enhancer of metal toxicants in molluscs | PURITCH GEORGE S (CA) | 2002-09-26 | — | — | US | claimed |
| EP-1052899-B1 | Enhancement of metal molluscicides by ethylene diamine disuccinic acid (EDDS) | NEUDORFF W GMBH KG (DE) | 2002-04-17 | — | — | EP | claimed |
| US-6352706-B1 | IRON, COPPER, ZINC AND/OR ALUMINUM COMPOUND; ETHYLENEDIAMINE DISUCCINIC ACID OR SALT OR COMPLEX THEREOF; AND CARRIER; STOMACH POISON | W. NEUDORFF GMBH KG (DE) | 2002-03-05 | — | — | US | claimed |
| EP-1052899-A1 | ENHANCEMENT OF METAL MOLLUSCICIDES BY ETHYLENE DIAMINE DISUCCINIC ACID | W. NEUDORFF GmbH KG (DE) | 2000-11-22 | — | — | EP | claimed |
| WO-1999039576-A1 | ENHANCEMENT OF METAL MOLLUSCICIDES BY ETHYLENE DIAMINE DISUCCINIC ACID | W. NEUDORFF GMBH KG (DE) | 1999-08-12 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150237850-A1 | COMPOSITION, METHOD AND USE | IDUA, ATP2A3, ATP2A1 | LMNA 972/4885EGLN1 1032/4885ALKBH5 3164/4885 |
| US-20120027832-A1 | USE OF EDDS AND CALCIUM IONS AS ENHANCERS OF MOLLUSCICIDAL ACTIVITY | ORAI1, ATP2A1, ACMSD | LMNA 2161/4885EGLN1 872/4885ALKBH5 3612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.