Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 2/20 | 0.56 |
| ▸ | MMP2 | P08253 | 4/20 | 0.48 |
| ▸ | MAOB | P27338 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 2/20 | 0.43 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 4/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4686959 | 0.87 | PTGER4 (0.73) | PTGER4MMP2MMP9FFAR1SMPD1 | |
| SCHEMBL3537874 | 0.86 | PTGER4 (0.76) | PTGER4MMP2MAOBRAB9AMMP13 | |
| SCHEMBL4691702 | 0.85 | PTGER4 (0.59) | PTGER4RAB9AADAMTS4FFAR1 | |
| SCHEMBL4686978 | 0.77 | PTGER4 (0.73) | PTGER4MMP2 | |
| SCHEMBL4687696 | 0.74 | PTGER4 (0.57) | PTGER4MMP2MMP13ADAMTS4MMP3 | |
| SCHEMBL4420254 | 0.73 | MMP2 (0.60) | PTGER4MMP2RAB9AMMP13MMP3 | |
| SCHEMBL3535821 | 0.72 | PTGER4 (1.00) | PTGER4FFAR1FFAR4AKR1B1 | |
| SCHEMBL16841039 | 0.72 | MAOB (0.72) | PTGER4MMP2MAOBRAB9AMMP13 | |
| SCHEMBL7372943 | 0.71 | MAOB (0.89) | MMP2MAOBRAB9AABCB1HPGD | |
| SCHEMBL4688386 | 0.71 | LMNA (0.57) | PTGER4MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603893-B1 | EP4 RECEPTOR ANTAGONISTS | ASTERAND UK LTD (GB) | 2008-05-21 | — | — | EP | claimed |