Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 12/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4233674 | 0.82 | HCAR3 (0.40) | CASP6TSHRHCAR3LMNA | |
| SCHEMBL4299408 | 0.81 | CASP6 (0.58) | CASP6TSHRPOLBHCAR3LMNA | |
| SCHEMBL29897189 | 0.81 | CASP6 (0.58) | CASP6TSHRPOLBHCAR3LMNA | |
| SCHEMBL1609806 | 0.81 | CASP6 (0.66) | CASP6TSHRPOLBHCAR3LMNA | |
| Hydrochloric Acid SCHEMBL1609389 | 0.79 | CASP6 (0.64) | CASP6TSHRPOLBHCAR3LMNA | |
| SCHEMBL4990608 | 0.78 | KMT2A (0.49) | TSHRPOLBLMNAMAPT | |
| SCHEMBL2263152 | 0.78 | ALOX15 (0.39) | TSHRLMNAMAPT | |
| SCHEMBL18027781 | 0.77 | CASP6 (0.66) | CASP6TSHRPOLBHCAR3LMNA | |
| SCHEMBL544105 | 0.77 | VCAM1 (0.54) | POLBLMNA | |
| SCHEMBL17399916 | 0.77 | CASP6 (0.60) | CASP6TSHRPOLBHCAR3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732887-B1 | 1-(1H-INDOL-1-YL)-3-(4-METHYLPIPERAZIN-1-YL)-1-PHENYL PROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE NOREPINEPHRINE (NE) AND THE SEROTONINE (5-HT) ACTIVITY AND THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) | WYETH CORP (US) | 2008-01-09 | — | — | EP | claimed |
| EP-1879887-A2 | NPY ANTAGONISTS, PREPARATION AND USE | Cerep (FR) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006108965-A2 | NPY ANTAGONISTS, PREPARATION AND USE | CEREP (FR) | 2006-10-19 | — | — | WO | disclosed |