Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2012035 | 0.90 | VCAM1 (0.53) | VCAM1MAPTSMN1; SMN2THRBLMNA | |
| SCHEMBL2007026 | 0.82 | CNR1 (0.47) | LMNATSHRMAPK1HSD11B1GAA | |
| SCHEMBL2002863 | 0.82 | L3MBTL1 (0.49) | TSHRGAA | |
| SCHEMBL2006592 | 0.81 | MEN1 (0.47) | MAPTSMN1; SMN2LMNAALDH1A1USP2 | |
| SCHEMBL2007289 | 0.81 | MEN1 (0.47) | MAPTSMN1; SMN2LMNAALDH1A1USP2 | |
| SCHEMBL4688564 | 0.81 | PKM (0.54) | MAPTSMN1; SMN2LMNAALDH1A1USP2 | |
| SCHEMBL3135736 | 0.80 | VCAM1 (0.51) | VCAM1MAPTSMN1; SMN2THRBLMNA | |
| SCHEMBL2000970 | 0.79 | VCAM1 (0.42) | VCAM1MAPTSMN1; SMN2THRBLMNA | |
| SCHEMBL2006521 | 0.77 | PKM (0.49) | MAPTSMN1; SMN2LMNAALDH1A1TSHR | |
| SCHEMBL2007303 | 0.77 | PKM (0.57) | SMN1; SMN2LMNAALDH1A1TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981504-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | NV Remynd (BE) | 2008-10-22 | — | — | EP | claimed |
| WO-2007090617-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | NV REMYND (BE) | 2007-08-16 | — | — | WO | claimed |