Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | FNTA | P49354 | 1/20 | 0.46 |
| ▸ | FNTB | P49356 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4688671 | 0.86 | TSHR (0.51) | LMNAL3MBTL1ALDH1A1ADAMTS5MAPT | |
| SCHEMBL4692247 | 0.80 | ADAMTS5 (0.54) | LMNAL3MBTL1ALDH1A1ADAMTS5MAPT | |
| SCHEMBL4693971 | 0.79 | THRB (0.53) | LMNAL3MBTL1ALDH1A1ADAMTS5MAPT | |
| SCHEMBL13113991 | 0.78 | THRB (0.57) | LMNAL3MBTL1ALDH1A1ADAMTS5MAPT | |
| SCHEMBL28333236 | 0.75 | RAB9A (0.48) | LMNAALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL10872622 | 0.72 | POLB (0.60) | L3MBTL1ALDH1A1ADAMTS5KMT2AMEN1 | |
| SCHEMBL11664167 | 0.72 | SMN1; SMN2 (0.72) | LMNAL3MBTL1ALDH1A1MAPTHTT | |
| SCHEMBL3528214 | 0.71 | SMN1; SMN2 (0.54) | LMNAL3MBTL1ALDH1A1THRBKMT2A | |
| SCHEMBL14112020 | 0.71 | KMT2A (0.79) | L3MBTL1ALDH1A1ADAMTS5THRBHTT | |
| SCHEMBL27917919 | 0.71 | LMNA (0.49) | LMNAL3MBTL1ALDH1A1ADAMTS5THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1496838-A4 | SUBSTITUTED AMIDES | MERCK & CO INC (US) | 2008-07-02 | — | — | EP | claimed |
| EP-1496838-A2 | SUBSTITUTED AMIDES | Merck & Co., Inc. (US) | 2005-01-19 | — | — | EP | claimed |
| WO-2003077847-A2 | SUBSTITUTED AMIDES | MERCK & CO., INC. (US) | 2003-09-25 | — | — | WO | claimed |
| EP-1496838-A4 | SUBSTITUTED AMIDES | MERCK & CO INC (US) | 2008-07-02 | — | — | EP | disclosed |
| EP-1496838-A2 | SUBSTITUTED AMIDES | Merck & Co., Inc. (US) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003077847-A2 | SUBSTITUTED AMIDES | MERCK & CO., INC. (US) | 2003-09-25 | — | — | WO | disclosed |