Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 4/20 | 0.53 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692247 | 0.99 | ADAMTS5 (0.54) | THRBADAMTS5TP53SMN1; SMN2KMT2A | |
| SCHEMBL4689029 | 0.81 | ADORA3 (0.45) | SMN1; SMN2LMNAMAPTALDH1A1POLB | |
| SCHEMBL4691514 | 0.80 | GPR139 (0.47) | ADAMTS5RAB9AKMT2AMEN1NPC1 | |
| SCHEMBL4688551 | 0.80 | ADORA3 (0.46) | SMN1; SMN2LMNAMAPTALDH1A1POLB | |
| SCHEMBL2653467 | 0.79 | CNR1 (0.62) | SMN1; SMN2HTTMAPTALDH1A1POLB | |
| SCHEMBL4689641 | 0.79 | LMNA (0.52) | THRBADAMTS5TP53SMN1; SMN2KMT2A | |
| SCHEMBL4691613 | 0.79 | CNR1 (0.62) | SMN1; SMN2HTTMAPTALDH1A1POLB | |
| SCHEMBL5262774 | 0.78 | SLC6A9 (0.54) | TP53SMN1; SMN2RAB9AKMT2AMEN1 | |
| SCHEMBL4688417 | 0.78 | GPR139 (0.48) | ADAMTS5RAB9AKMT2AMEN1NPC1 | |
| SCHEMBL4690861 | 0.78 | CNR1 (0.63) | SMN1; SMN2HTTMAPTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1496838-A4 | SUBSTITUTED AMIDES | MERCK & CO INC (US) | 2008-07-02 | — | — | EP | claimed |
| EP-1496838-A2 | SUBSTITUTED AMIDES | Merck & Co., Inc. (US) | 2005-01-19 | — | — | EP | claimed |
| WO-2003077847-A2 | SUBSTITUTED AMIDES | MERCK & CO., INC. (US) | 2003-09-25 | — | — | WO | claimed |
| EP-1496838-A4 | SUBSTITUTED AMIDES | MERCK & CO INC (US) | 2008-07-02 | — | — | EP | disclosed |
| EP-1496838-A2 | SUBSTITUTED AMIDES | Merck & Co., Inc. (US) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003077847-A2 | SUBSTITUTED AMIDES | MERCK & CO., INC. (US) | 2003-09-25 | — | — | WO | disclosed |