SCHEMBL4689727

SCHEMBL4689727

NC(=O)C1[C@@H]2CN(C(=O)c3cnc4ccccc4c3)CC2CN1CC[CH]c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 3/20 0.45
CAPN1 P07384 1/20 0.40
MGAM O43451 1/20 0.38
CHRNB2 P17787 1/20 0.37
CHRNA7 P36544 1/20 0.37
CHRNA4 P43681 1/20 0.37
HDAC3 O15379 1/20 0.37
HDAC4 P56524 1/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC7 Q8WUI4 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC10 Q969S8 1/20 0.37
HDAC11 Q96DB2 1/20 0.37
HDAC8 Q9BY41 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37
HDAC9 Q9UKV0 1/20 0.37
HDAC5 Q9UQL6 1/20 0.37
KDM2B Q8NHM5 1/20 0.37
CFTR P13569 1/20 0.37
CCR3 P51677 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4694358 0.90 DPP4 (0.45) DPP4CAPN1HDAC3HDAC4HDAC1
SCHEMBL5232784 0.86 CHRNB2 (0.43) CHRNB2CHRNA7CHRNA4
SCHEMBL4691215 0.86 DPP4 (0.44) DPP4
SCHEMBL4696396 0.83 TSHR (0.41) DPP4MGAMKDM2BRAB9A
SCHEMBL5235498 0.83 HDAC3 (0.38) DPP4CHRNB2CHRNA7CHRNA4HDAC3
SCHEMBL3283159 0.82 CHRNB2 (0.47) CHRNB2CHRNA7CHRNA4
SCHEMBL4694474 0.80 MAPK1 (0.40) CHRNB2CHRNA7CHRNA4
SCHEMBL4691766 0.80 CHRNB2 (0.47) CHRNB2CHRNA7CHRNA4RAB9A
SCHEMBL4693442 0.80 EIF4A3 (0.37) CCR3
SCHEMBL4695167 0.80 CYP2D6 (0.38) CHRNB2CHRNA7CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP claimed
EP-1761542-A2 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 2007-03-14 EP claimed
WO-2005121145-A2 OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2005-12-22 WO claimed
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP disclosed