Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4A3 | P38919 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5236228 | 0.83 | HCRTR2 (0.45) | HCRTR2HCRTR1 | |
| SCHEMBL5232784 | 0.83 | CHRNB2 (0.43) | — | |
| SCHEMBL4691766 | 0.83 | CHRNB2 (0.47) | MAPT | |
| SCHEMBL4692182 | 0.82 | HCRTR1 (0.47) | CCR3HCRTR2HCRTR1 | |
| SCHEMBL5231921 | 0.82 | P2RX7 (0.40) | — | |
| SCHEMBL5233193 | 0.81 | HTT (0.42) | MAPTPDE2A | |
| SCHEMBL4691215 | 0.81 | DPP4 (0.44) | HCRTR2HCRTR1 | |
| SCHEMBL4695167 | 0.80 | CYP2D6 (0.38) | — | |
| SCHEMBL4696396 | 0.80 | TSHR (0.41) | HCRTR2HCRTR1MAPT | |
| SCHEMBL4694358 | 0.80 | DPP4 (0.45) | CCR3PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |