SCHEMBL4694358

SCHEMBL4694358

NC(=O)C1[C@@H]2CN(C(=O)c3ccc4ncccc4c3)CC2CN1CC[CH]c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 1/20 0.45
DPP8 Q6V1X1 1/20 0.45
CAPN1 P07384 1/20 0.42
CCR3 P51677 6/20 0.37
LMNA P02545 2/20 0.37
HTR3A P46098 1/20 0.37
CNR1 P21554 1/20 0.37
CNR2 P34972 1/20 0.37
ALDH1A1 P00352 2/20 0.36
PDE2A O00408 1/20 0.36
HDAC3 O15379 1/20 0.36
HDAC4 P56524 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC10 Q969S8 1/20 0.36
HDAC11 Q96DB2 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
HDAC9 Q9UKV0 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4689727 0.90 DPP4 (0.45) DPP4DPP8CAPN1CCR3CNR1
SCHEMBL5235498 0.85 HDAC3 (0.38) DPP4DPP8ALDH1A1PDE2AHDAC3
SCHEMBL5232784 0.85 CHRNB2 (0.43) ALDH1A1SMN1; SMN2HPGDKCNH2
SCHEMBL4692182 0.83 HCRTR1 (0.47) CCR3ALDH1A1HTR2A
SCHEMBL3283159 0.83 CHRNB2 (0.47) LMNAALDH1A1SMN1; SMN2HPGDCYP3A4
SCHEMBL4691766 0.82 CHRNB2 (0.47) LMNAALDH1A1SMN1; SMN2HPGD
SCHEMBL5236228 0.81 HCRTR2 (0.45) ALDH1A1
SCHEMBL4694474 0.81 MAPK1 (0.40) LMNAALDH1A1SMN1; SMN2HPGDCYP3A4
SCHEMBL4693442 0.80 EIF4A3 (0.37) CCR3PDE2A
SCHEMBL4696396 0.80 TSHR (0.41) DPP4ALDH1A1SMN1; SMN2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP claimed
EP-1761542-A2 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 2007-03-14 EP claimed
WO-2005121145-A2 OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2005-12-22 WO claimed
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP disclosed