Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.51 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.45 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.43 |
| ▸ | CCL5 | P13501 | 7/20 | 0.42 |
| ▸ | CCR5 | P51681 | 6/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694361 | 0.88 | DPP4 (0.50) | DPP4CAPN1CCL5CCR5HDAC3 | |
| SCHEMBL4691220 | 0.84 | DPP4 (0.50) | DPP4CCL5CCR5 | |
| SCHEMBL4694458 | 0.83 | CCR5 (0.53) | CCL5CCR5 | |
| SCHEMBL4696398 | 0.81 | GRIN2B (0.48) | DPP4MGAMKDM2BCCL5CCR5 | |
| SCHEMBL4695119 | 0.80 | HDAC3 (0.42) | DPP4CCL5CCR5HDAC3HDAC4 | |
| SCHEMBL3283162 | 0.79 | CHRNB2 (0.54) | CCL5CCR5 | |
| SCHEMBL5236953 | 0.79 | DPP4 (0.50) | DPP4CAPN1MGAMKDM2BHDAC3 | |
| SCHEMBL4693123 | 0.79 | CCR5 (0.50) | CCL5CCR5 | |
| SCHEMBL4694095 | 0.78 | CCR5 (0.51) | CCL5CCR5 | |
| SCHEMBL4695293 | 0.77 | CCR5 (0.46) | CCL5CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |