Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 4/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4690722 | 0.86 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL4694319 | 0.85 | CRHR1 (0.37) | CRHR1CRHR2TLR8 | |
| SCHEMBL3972523 | 0.81 | CRHR1 (0.58) | CRHR1CRHR2ALDH1A1 | |
| SCHEMBL4690582 | 0.77 | CRHR1 (0.53) | CRHR1CRHR2 | |
| SCHEMBL4694389 | 0.77 | CYP2A6 (0.36) | CRHR1TLR8 | |
| SCHEMBL4787114 | 0.74 | TLR8 (0.38) | CRHR1CRHR2TLR8ALDH1A1 | |
| SCHEMBL4693619 | 0.73 | CRHR1 (0.67) | CRHR1CRHR2ALDH1A1 | |
| SCHEMBL4693477 | 0.73 | CRHR1 (0.67) | CRHR1CRHR2ALDH1A1 | |
| SCHEMBL4689862 | 0.72 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL4694406 | 0.72 | CRHR1 (0.33) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879896-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006107784-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-10-12 | — | — | WO | disclosed |