Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 4/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694546 | 0.85 | CRHR1 (0.39) | CRHR1CRHR2TLR8 | |
| SCHEMBL3973096 | 0.81 | CRHR1 (0.55) | CRHR1CRHR2PDE10APOLBKMT2A | |
| SCHEMBL4694389 | 0.81 | CYP2A6 (0.36) | CRHR1NPC1PDE10ATLR8 | |
| SCHEMBL4690722 | 0.76 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL4690582 | 0.76 | CRHR1 (0.53) | CRHR1CRHR2ADORA3 | |
| SCHEMBL4787114 | 0.74 | TLR8 (0.38) | CRHR1CRHR2ADORA3TLR8 | |
| SCHEMBL3959632 | 0.71 | CRHR1 (0.65) | CRHR1CRHR2PDE10APOLBKMT2A | |
| SCHEMBL4693619 | 0.71 | CRHR1 (0.67) | CRHR1CRHR2HPGDPDE10AADORA3 | |
| SCHEMBL4693477 | 0.71 | CRHR1 (0.67) | CRHR1CRHR2HPGDPDE10AADORA3 | |
| SCHEMBL4689862 | 0.70 | CRHR1 (0.45) | CRHR1HPGDPDE10AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879896-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006107784-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-10-12 | — | — | WO | disclosed |