Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 2/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 16/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 15/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4690567 | 0.83 | CCR5 (0.51) | CCR5HCRTR2HCRTR1KMT2A | |
| SCHEMBL4695963 | 0.81 | HCRTR1 (0.39) | CCR5HCRTR2HCRTR1 | |
| SCHEMBL4693258 | 0.80 | HCRTR1 (0.41) | CCR5HCRTR2HCRTR1KMT2A | |
| SCHEMBL4694113 | 0.78 | CHRNB2 (0.40) | CCR5KMT2ASMN1; SMN2 | |
| SCHEMBL4690598 | 0.78 | CCR5 (0.55) | CCR5HCRTR2HCRTR1 | |
| SCHEMBL4695464 | 0.77 | HCRTR1 (0.44) | CCR5HCRTR2HCRTR1 | |
| SCHEMBL4695357 | 0.77 | GAA (0.45) | HCRTR2HCRTR1 | |
| SCHEMBL4691895 | 0.77 | HCRTR1 (0.33) | CCR5HCRTR2HCRTR1 | |
| SCHEMBL4692504 | 0.76 | HCRTR1 (0.44) | CCR5HCRTR2HCRTR1KMT2A | |
| SCHEMBL4690600 | 0.75 | SMN1; SMN2 (0.39) | CCR5HCRTR2HCRTR1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |