SCHEMBL4692369

SCHEMBL4692369

N#CC(CC(F)(F)F)c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.42
TSHR P16473 1/20 0.42
CTSL P07711 5/20 0.37
CTSS P25774 1/20 0.35
CTSK P43235 1/20 0.35
ALDH1A1 P00352 4/20 0.35
ESR1 P03372 3/20 0.35
ESR2 Q92731 3/20 0.35
MEN1 O00255 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
KMT2A Q03164 1/20 0.35
HTT P42858 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
NPSR1 Q6W5P4 2/20 0.33
USP2 O75604 1/20 0.33
LMNA P02545 1/20 0.33
HPGD P15428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28620293 0.77 CES1 (0.44) TSHRCTSLCTSSCTSKALDH1A1
SCHEMBL1344877 0.76 TSHR (0.50) TRPA1TSHRALDH1A1ESR1ESR2
SCHEMBL28622050 0.74 LMNA (0.43) TSHRCTSLALDH1A1ESR1ESR2
SCHEMBL8103989 0.74 ALDH1A1 (0.40) TRPA1TSHRALDH1A1MEN1CYP1A2
SCHEMBL8419059 0.74 SIGMAR1 (0.42) CTSLCTSSCTSKMEN1CYP1A2
SCHEMBL22338325 0.73 TSHR (0.48) TRPA1TSHRALDH1A1ESR1ESR2
SCHEMBL9057427 0.73 HTR2A (0.46) TSHRALDH1A1RAB9AHTR2ATAAR1
SCHEMBL23199874 0.72 TSHR (0.52) TRPA1TSHRALDH1A1ESR1ESR2
SCHEMBL3240433 0.72 TSHR (0.46) TRPA1TSHRALDH1A1ESR1ESR2
SCHEMBL1094363 0.72 TSHR (0.52) TRPA1TSHRALDH1A1ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104701570-A Non-aqueous organic high-voltage electrolyte additive, non-aqueous organic high-voltage electrolyte and lithium ion secondary battery HUAWEI TECH CO LTD 2015-06-10 CN disclosed
EP-1501803-B1 TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROISOQUINOLINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO INC (US) 2008-08-13 EP disclosed
EP-1501803-A4 TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROISOQUINOLINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO INC (US) 2006-04-26 EP disclosed
EP-1501803-A2 TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROISOQUINOLINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Merck & Co., Inc. (US) 2005-02-02 EP disclosed
WO-2003093231-A2 TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROISOQUINOLINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2003-11-13 WO disclosed