Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694302 | 0.85 | MAPT (0.55) | TP53MAPTLMNAHTT | |
| SCHEMBL4694331 | 0.85 | TP53 (0.47) | TP53MAPTALDH1A1LMNAGLA | |
| SCHEMBL4695294 | 0.85 | MAPT (0.58) | TP53MAPTLMNAKMT2AHTT | |
| SCHEMBL4690401 | 0.83 | TP53 (0.47) | TP53MAPTALDH1A1LMNAGLA | |
| SCHEMBL4693288 | 0.82 | KMT2A (0.56) | TP53MAPTALDH1A1KMT2AHTT | |
| SCHEMBL3286924 | 0.82 | TP53 (0.53) | TP53MAPTALDH1A1LMNAGLA | |
| SCHEMBL4695191 | 0.82 | ALDH1A1 (0.52) | TP53MAPTALDH1A1LMNAGLA | |
| SCHEMBL3283676 | 0.82 | TP53 (0.53) | TP53MAPTALDH1A1LMNAKMT2A | |
| SCHEMBL4692449 | 0.81 | ALDH1A1 (0.46) | MAPTALDH1A1EPHX2HTT | |
| SCHEMBL4690733 | 0.81 | HCRTR1 (0.46) | TP53MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |