Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4693295 | 0.83 | ALDH1A1 (0.48) | KMT2AALDH1A1GAAMAPTMEN1 | |
| SCHEMBL4692445 | 0.82 | TP53 (0.48) | KMT2AALDH1A1MAPTHTTTP53 | |
| SCHEMBL3283676 | 0.80 | TP53 (0.53) | KMT2AALDH1A1MAPTMEN1HTT | |
| SCHEMBL4694338 | 0.79 | TP53 (0.45) | KMT2AALDH1A1MAPTMEN1RAB9A | |
| SCHEMBL3286924 | 0.79 | TP53 (0.53) | KMT2AALDH1A1MAPTMEN1TP53 | |
| SCHEMBL4694302 | 0.79 | MAPT (0.55) | MAPTRAB9AHTTTP53SMN1; SMN2 | |
| SCHEMBL4695191 | 0.79 | ALDH1A1 (0.52) | KMT2AALDH1A1GAAMAPTTP53 | |
| SCHEMBL4695294 | 0.78 | MAPT (0.58) | KMT2AMAPTMEN1HTTTP53 | |
| SCHEMBL3281859 | 0.78 | CCR5 (0.52) | KMT2AALDH1A1GAAMEN1HTT | |
| SCHEMBL4695971 | 0.77 | LMNA (0.50) | KMT2AALDH1A1MAPTMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |