Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4693588 | 0.86 | UBE2M (0.46) | ALDH1A1SMN1; SMN2MAPTLMNAKMT2A | |
| SCHEMBL4695196 | 0.83 | MAPT (0.43) | ALDH1A1SMN1; SMN2GAAMAPTKMT2A | |
| SCHEMBL4692445 | 0.82 | TP53 (0.48) | ALDH1A1MAPTLMNAGLAKMT2A | |
| SCHEMBL4691609 | 0.81 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2GAAMAPTLMNA | |
| SCHEMBL4693288 | 0.79 | KMT2A (0.56) | ALDH1A1SMN1; SMN2GAAMAPTKMT2A | |
| SCHEMBL3286924 | 0.78 | TP53 (0.53) | ALDH1A1SMN1; SMN2MAPTLMNAGLA | |
| SCHEMBL3283676 | 0.78 | TP53 (0.53) | ALDH1A1SMN1; SMN2MAPTLMNAKMT2A | |
| SCHEMBL4694302 | 0.78 | MAPT (0.55) | SMN1; SMN2MAPTLMNATP53USP2 | |
| SCHEMBL4690531 | 0.78 | MAPT (0.48) | ALDH1A1SMN1; SMN2GAAMAPTBLM | |
| SCHEMBL4693905 | 0.78 | HCRTR1 (0.48) | ALDH1A1GAAMAPTLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |