Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | FPR2 | P25090 | 7/20 | 0.54 |
| ▸ | PROKR1 | Q8TCW9 | 7/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692445 | 0.85 | TP53 (0.48) | MAPTTP53LMNAHTT | |
| SCHEMBL4694262 | 0.84 | SMN1; SMN2 (0.48) | MAPTSMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL4695294 | 0.84 | MAPT (0.58) | MAPTSMN1; SMN2TP53POLBLMNA | |
| SCHEMBL4694306 | 0.83 | FPR2 (0.56) | FPR2PROKR1 | |
| SCHEMBL3283676 | 0.81 | TP53 (0.53) | MAPTSMN1; SMN2TP53POLBLMNA | |
| SCHEMBL4693288 | 0.79 | KMT2A (0.56) | MAPTSMN1; SMN2RAB9ATP53HTT | |
| SCHEMBL3286924 | 0.78 | TP53 (0.53) | MAPTSMN1; SMN2TP53LMNATSHR | |
| SCHEMBL4690880 | 0.78 | TP53 (0.50) | MAPTSMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL4695191 | 0.78 | ALDH1A1 (0.52) | MAPTSMN1; SMN2TP53USP2LMNA | |
| SCHEMBL3282221 | 0.77 | CCR5 (0.51) | MAPTSMN1; SMN2TP53LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |