Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 14/20 | 0.44 |
| ▸ | EBP | Q15125 | 1/20 | 0.44 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694306 | 0.85 | FPR2 (0.56) | — | |
| SCHEMBL4696048 | 0.85 | FPR2 (0.48) | GAAMAPT | |
| SCHEMBL4695297 | 0.84 | LMNA (0.50) | ALDH1A1GAAHTTMAPT | |
| SCHEMBL13326676 | 0.84 | ALDH1A1 (0.41) | ALDH1A1GAAHTTFKBP1AMAPT | |
| SCHEMBL4694337 | 0.82 | CCR5 (0.43) | ALDH1A1GAAHTTMAPT | |
| SCHEMBL3283552 | 0.82 | CCR1 (0.42) | ALDH1A1EPHX2GAAHTTFKBP1A | |
| SCHEMBL4693295 | 0.82 | ALDH1A1 (0.48) | ALDH1A1GAAHTTMAPT | |
| SCHEMBL4692445 | 0.81 | TP53 (0.48) | ALDH1A1EPHX2HTTMAPT | |
| SCHEMBL4695196 | 0.81 | MAPT (0.43) | ALDH1A1GAAHTTMAPT | |
| SCHEMBL3283683 | 0.81 | MAPT (0.47) | ALDH1A1GAAHTTFKBP1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |