Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 9/20 | 0.37 |
| ▸ | CCL5 | P13501 | 8/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4695968 | 0.91 | LMNA (0.44) | LMNATSHRCCR5CCL5ALDH1A1 | |
| SCHEMBL4695866 | 0.87 | CCR5 (0.36) | CCR5CCL5ALDH1A1 | |
| SCHEMBL4696881 | 0.83 | CCL5 (0.38) | LMNATSHRCCR5CCL5ALDH1A1 | |
| SCHEMBL4692061 | 0.82 | CCR5 (0.37) | LMNACCR5CCL5ALDH1A1 | |
| SCHEMBL4695377 | 0.79 | CCR5 (0.37) | TSHRCCR5CCL5 | |
| SCHEMBL4695010 | 0.78 | KMT2A (0.38) | CCR5CCL5ALDH1A1 | |
| SCHEMBL4692781 | 0.78 | PKM (0.36) | LMNATSHRCCR5CCL5ALDH1A1 | |
| SCHEMBL4694111 | 0.78 | KMT2A (0.34) | CCR5ALDH1A1 | |
| SCHEMBL4694498 | 0.76 | CCR5 (0.37) | CCR5CCL5 | |
| SCHEMBL4691790 | 0.76 | CCR5 (0.42) | CCR5CCL5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |