Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 15/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 15/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3283294 | 0.84 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL4689931 | 0.84 | HCRTR1 (0.39) | HCRTR1HCRTR2PDE4BPDE4APDE4C | |
| SCHEMBL4693869 | 0.84 | CCR5 (0.43) | HCRTR1HCRTR2PDE4B | |
| SCHEMBL4694327 | 0.79 | HCRTR1 (0.48) | HCRTR1HCRTR2 | |
| SCHEMBL4693290 | 0.78 | PDE10A (0.40) | HCRTR1HCRTR2PDE4BPDE4APDE4C | |
| SCHEMBL4692311 | 0.78 | LMNA (0.47) | HCRTR1HCRTR2 | |
| SCHEMBL4697501 | 0.77 | P2RX7 (0.45) | — | |
| SCHEMBL3283985 | 0.74 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL4694034 | 0.72 | MALT1 (0.46) | MALT1 | |
| SCHEMBL4690542 | 0.72 | HCRTR1 (0.39) | HCRTR1HCRTR2PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |