Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.32 |
| ▸ | SLC9A2 | Q9UBY0 | 2/20 | 0.32 |
| ▸ | ACLY | P53396 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | LOX | P28300 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | FPR1 | P21462 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3282871 | 1.00 | RIPK2 (0.36) | RIPK2NPC1RAB9ASLC9A1SLC9A2 | |
| SCHEMBL4690864 | 0.83 | RIPK2 (0.40) | RIPK2NPC1RAB9ASLC9A1SLC9A2 | |
| SCHEMBL4693316 | 0.78 | EIF4A3 (0.39) | RIPK2RAB9APTGS1CA12CA1 | |
| SCHEMBL4691488 | 0.75 | FPR2 (0.37) | HPGDMAPT | |
| SCHEMBL4694244 | 0.72 | EIF4A3 (0.45) | SLC9A1SLC9A2PTGS2HPGDMAPT | |
| SCHEMBL4695049 | 0.71 | TSHR (0.39) | HPGDMEN1KMT2A | |
| SCHEMBL4691594 | 0.71 | FPR2 (0.34) | ACLYMAPT | |
| SCHEMBL4691732 | 0.70 | KDM4E (0.43) | KEAP1NFE2L2MAPTHSD11B1MAPK14 | |
| SCHEMBL4694498 | 0.70 | CCR5 (0.37) | — | |
| SCHEMBL4692781 | 0.70 | PKM (0.36) | HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |